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            中國科學(xué)院水生生物研究所歡迎您的來(lái)訪(fǎng)！
        
        
        
    
        

        

        
    
        
        
        
            
        
                
            
        
            
        
                
        
                    
                
        
            
        
        
        
    
        

        





        
    
        
        
        
            

        
        
        
        
            
        
                
                
                
        
					  
        
						  
        周炳升　研究員
        博士研究生
        
						  
        
							
        
								
        
							
        
							
        
								
        
                                    
        
                                            
                                              
        
                                                職　　稱(chēng)：
                                                研究員
                                              
        
                                              
        
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                                                博士研究生
                                              
        
                                              
        
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                                                86-27-68780042
                                              
        
                                              
        
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                                                bszhou@ihb.ac.cn
                                              
        
                                              
        
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        教育經(jīng)歷
                    
                                
        1982.9-1986.6 武漢大學(xué) 生物系 細胞生物學(xué)專(zhuān)業(yè) 本科
                    
        1986.9-1989.6 武漢大學(xué) 生物系 動(dòng)物學(xué)專(zhuān)業(yè) 碩士
                    
        1997.5-2000.12 香港城市大學(xué) 生物與化學(xué)系 環(huán)境毒理學(xué)專(zhuān)業(yè)博士
                            		        
            
        主要職歷
                    
                                
        1989.7-1995.8中國科學(xué)院水生生物研究所，研究實(shí)習員、助理研究員
                    
        1995.9-1996.10香港城市大學(xué)生物與化學(xué)系，研究助理
                    
        2001.7-2003.6加拿大McMaster大學(xué)生物系，博士后
                    
        2003.7-2004.12 香港城市大學(xué)，海岸污染與生態(tài)毒理學(xué)研究中心，博士后
                    
        2005.1-至今 中國科學(xué)院水生生物研究所，水環(huán)境工程研究中心，研究員
                            		        
            
        招生專(zhuān)業(yè)
                    
                                
        水生生物學(xué)（碩士生，博士生）
                            		        
            
        研究方向
                    
                                
        環(huán)境毒理學(xué)，特別是基于水環(huán)境中典型有機污染物對水生生物的毒性效應、風(fēng)險評價(jià)、健康危害以及毒理機制的研究，并發(fā)展有機污染物水生態(tài)風(fēng)險評價(jià)的技術(shù)和方法，以及典型有機污染物在水環(huán)境中的行為、轉移規律。
                            		        
            
        承擔項目情況
                    
                                
        1.         國家自然科學(xué)基金委員會(huì )，面上項目，典型溴代阻燃劑與納米二氧化鈦、有機碳相互作用誘導的斑馬魚(yú)甲狀腺內分泌干擾效應，2020-01至2023-12, 主持。
                    
        2.         國家重點(diǎn)研發(fā)計劃藍色糧倉科技創(chuàng  )新重點(diǎn)專(zhuān)項“典型養殖系統對自然水域生態(tài)系統的影響機理”項目，課題“池塘養殖物質(zhì)循環(huán)及對湖泊生態(tài)系統的影響機理”。2018-12至2022-12，主持課題。
                    
        3.         國家自然科學(xué)基金委員會(huì )，重點(diǎn)項目，新興溴代阻燃劑的水環(huán)境暴露、毒性效應及分子機制，2018-01至2022-12,主持。
                    
        4.         國家科技重大專(zhuān)項, 南水北調中線(xiàn)輸水水質(zhì)預警與業(yè)務(wù)化管理平臺，南水北調課題：中線(xiàn)總干渠重金屬與持久性有機污染物的時(shí)空格局及其生態(tài)風(fēng)險，2017-01至2021-06，參加。
                    
        5.         中科院先導專(zhuān)項B，典型內分泌干擾物對斑馬魚(yú)發(fā)育毒性效應與分子機制研究，2014-06至2018-12，主持子課題。
                    
        6.         環(huán)保部公益項目，電子廢棄物溴代阻燃劑和重金屬復合污染的人體評價(jià)技術(shù)研究，2013-01-2016-12，參加。
                    
        7.         科技部863計劃，溴代阻燃劑的暴露和效應評估新技術(shù)，2007-01至2009-12，主持。
                    
        8.         國家自然科學(xué)基金委員會(huì )，面上項目，納米TiO2與典型有機污染物的復合暴露對斑馬魚(yú)的毒性效應，2016-01至2019-12，主持。
                    
        9.         國家自然科學(xué)基金委員會(huì )，面上項目，水環(huán)境中的孕激素類(lèi)污染物對斑馬魚(yú)的內分泌干擾效應和分子機制，2013-01至2016-12，主持。
                    
        10.     國家自然科學(xué)基金委員會(huì )，重點(diǎn)項目，有機農藥與含銅鋅無(wú)機農藥的協(xié)同毒性作用機理研究，2013-01至2017-12，參加。
                    
        11.     中科院知識創(chuàng  )新重要方向項目，離體細胞系的構建和有毒污染物離體篩選技術(shù)的研究，2008-01至2010-12，主持子課題。
                    
        12.     國家自然科學(xué)基金委員會(huì )，重大項目，典型持久性有機污染物的環(huán)境過(guò)程與毒理效應，2009-01至2012-12，主持項目中的課題，典型持久性有機污染物的毒理學(xué)效應。
                    
        13.     國家自然科學(xué)基金委員會(huì )，面上項目，典型全氟代有機污染物對斑馬魚(yú)的發(fā)育毒性及雌激素效應的機理研究，2009-01至2011-12，主持。
                    
        14.     國家自然科學(xué)基金委員會(huì )，面上項目，有機污染物全氟辛烷磺?；衔锏姆肿由鷳B(tài)毒理學(xué)效應及危險評價(jià)，2006-01至2008-12，主持。
                    
        15.     中科院知識創(chuàng  )新重要方向項目，持久性有機污染物的分子生態(tài)毒理學(xué)效應與生物可降解性研究，2005-01至2007-12，主持。
                    
        16.     中國科學(xué)院，百人計劃人才項目，2005-01至2007-12，主持。
                            		        
            
        科研成果
                    
                                
        發(fā)展了以斑馬魚(yú)早期發(fā)育敏感期為對象的生物毒性測試方法，推進(jìn)了小型模式魚(yú)類(lèi)胚胎期在評價(jià)污染物毒理學(xué)效應研究中的應用。建立了水體中鈦納米顆粒的檢測技術(shù)，明確納米二氧化鈦可作為有機污染物和重金屬的載體，增強對魚(yú)類(lèi)的毒性。發(fā)現多溴聯(lián)苯醚和有機磷阻燃劑三(1,3-二氯-2-丙基)磷酸鹽（TDCIPP）可經(jīng)由母代積累傳遞給子代，引起對子代的健康危害。揭示了魚(yú)類(lèi)早期發(fā)育階段有機磷阻燃劑TDCIPP暴露引起成年期神經(jīng)毒性的表觀(guān)遺傳學(xué)機制。發(fā)現新溴代阻燃劑四溴鄰苯二甲酸雙酯（TBPH）干擾斑馬魚(yú)脂質(zhì)代謝、引起非酒精性脂肪肝以及表觀(guān)修飾的作用。
                    
         
                    
        代表性論文：
                    
        1.       Wei Guo, Lei Lei, Xiongjie Shi, Ruiwen Li, Qiangwei Wang, Jian Han, Lihua Yang, Lianguo Chen, Bingsheng Zhou*, 2021. Nonalcoholic Fatty Liver Disease Development in Zebrafish upon Exposure to Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate, a Novel Brominated Flame Retardant. Environ. Sci. & Technol., 55, 6926-6935.
                    
        2.       Qipeng Shi, Wei Guo, Qiancheng Shen, Jian Han, Lei Lei, Lianguo Chen, Lihua Yang, Chenglian Feng, Bingsheng Zhou*, 2021. In vitro biolayer interferometry analysis of acetylcholinesterase as a potential target of aryl-organophosphorus flame-retardants. Journal of Hazardous Materials, 409, 124999.
                    
        3.       Xiangping Chen, Wei Guo, Lei Lei, Yongyong Guo, Lihua Yang, Jian Han, Bingsheng Zhou*. 2021. Bioconcentration and developmental neurotoxicity of novel brominated flame retardants, hexabromobenzene and pentabromobenzene in zebrafish. Environmental Pollution, 268, 115895. 
                    
        4.       Wei Guo, Jian Han, Shengmin Wu, Xiongjie Shi, Bingsheng Zhou*, 2020. Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate affects lipid metabolism in zebrafish larvae via DNA methylation modification. Environ. Sci. & Technol., 54, 355-363.
                    
        5.       Ruiwen Li, Wei Guo, Lei Lei, Ling Zhang, Yunhao Liu, Jian Han, Lianguo Chen, Bingsheng Zhou*, 2020. Early-life exposure to the organophosphorus flame retardant tris (1, 3-dichloro-2-propyl) phosphate induces delayed neurotoxicity associated with DNA methylation in adult zebrafish. Environment International 134, 105293.
                    
        6.       Shengmin Wu, Shenghu Zhang, Yang Gong, Lili Shi, Bingsheng Zhou*, 2020. Identification and quantification of titanium nanoparticles in surface water: A case study in Lake Taihu, China. Journal of Hazardous materials, 382, 121045.
                    
        7.       Lianguo Chen*, James C. W. Lam, Lizhu Tang, Chenyan Hu, Mengyuan Liu, Paul K. S. Lam, Bingsheng Zhou*, 2020. Probiotic Modulation of Lipid Metabolism Disorders Caused by Perfluorobutanesulfonate Pollution in Zebrafish. Environ. Sci. & Technol., 54, 7494-7503.
                    
        8.       Xiaochen Wang, Siyuan Ling, Kelan Guan, Xiaojun Luo, Lianguo Chen, Jian Han,Wei Zhang, Bixian Mai, Bingsheng Zhou*, 2019. Bioconcentration, Biotransformation, and Thyroid Endocrine Disruption of Decabromodiphenyl Ethane (DBDPE), A Novel Brominated Flame Retardant, in Zebrafish Larvae. Environ. Sci. & Technol., 53, 8437-8446.
                    
        9.       Yongyong Guo, Lianguo Chen, Juan Wu, Jianghuan Hua, Lihua Yang, Wei Zhang, Bingsheng Zhou*, 2019. Transgenerational Effects of Parental Bisphenol A and Nano-TiO2 Co-exposure on the Thyroid Endocrine System and Neurodevelopment of Zebrafish Offspring. Sci Total Environ, 650, 557-565.
                    
        10.   Lianguo Chen, Chenyan Hu, Mirabelle M. P. Tsui, Teng Wan, Drew R. Peterson, Qipeng Shi, Paul K. S. Lam, Doris W. T. Au, James C. W. Lam*, Bingsheng Zhou*, 2018. Multigenerational Disruption of Thyroid Endocrine System in Marine Medaka after A Life-Cycle Exposure to Perfluorobutane Sulfonate (PFBS). Environ Sci & Technol, 52, 4432-4439.  
                    
        11.   Lianguo Chen, Weipeng Zhang, Chenyan Hu, Nelson Lok-Shun Lai, Jianghuan Hua, Paul K.S. Lam, James Lam*, Bingsheng Zhou*, 2018. Acute exposure to PBDEs at an environmentally realistic concentration causes abrupt changes in the gut microbiota and host health of zebrafish. Environmental Pollution 240, 17-26.
                    
        12.   Lianguo Chen, Yongyong Guo, Chenyan Hu, Paul K.S. Lam, James CW Lam*, Bingsheng Zhou*, 2018. Dysbiosis of gut microbiota by chronic coexposure to titanium dioxide nanoparticles and bisphenol A: Implications for host health in zebrafish. Environmental Pollution, 234, 307-317.
                    
        13.   Chen L, Zhang W, Hua J, Hu C, Lok-Shun Lai N, Qian PY, Lam PKS, Lam JCW, Zhou B*. 2018. Dysregulation of Intestinal Health by Environmental Pollutants: Involvement of the Estrogen Receptor and Aryl Hydrocarbon Receptor. Environ Sci & Technol., 52, 2323-2330. 
                    
        14.   Li R, Zhou P*, Guo Y, Lee JS, Zhou B*, 2017. Tris (1, 3-dichloro-2-propyl) phosphate induces apoptosis and autophagy in SH-SY5Y cells: Involvement of ROS-mediated AMPK/mTOR/ULK1 pathways. Food & Chemical Toxicology 100, 183-196.
                    
        15.   Chen L, Au DWT, Hu C, Peterson DR, Zhou B* and Qian PY*, 2017. Identification of Molecular Targets for 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) in Teleosts: New Insight into Mechanism of Toxicity. Environ Sci &Technol 51, 1840-1847. 
                    
        16.   Lianguo Chen, Xianfeng Wang, Xiaohua Zhang, Paul K.S. Lam, Yongyong Guo, James C.W. Lam*, Bingsheng Zhou*, 2017. Transgenerational endocrine disruption and neurotoxicity in zebrafish larvae after parental exposure to binary mixtures of decabromodiphenyl ether (BDE-209) and lead. Environmental Pollution 230, 96-106.
                    
        17.   Hua J, Han J, Wang X, Guo Y, Zhou B*, 2016. The binary mixtures of megestrol acetate and 17a-ethynylestradiol adversely affect zebrafish reproduction. Environmental Pollution 213, 776-784.
                    
        18.   Lianguo Chen, Biran Zhu, Yongyong Guo, Tao Xu, Jae-Seong Lee, Pei-Yuan Qian, Bingsheng Zhou*, 2016. High-throughput transcriptome sequencing reveals the combined effects of key e-waste contaminants, decabromodiphenyl ether (BDE- 209) and lead, in zebrafish larvae. Environmental Pollution 214, 324-333.
                    
        19.   Qi Fang, Qipeng Shi, Yongyong Guo, Jianghuan Hua, Xianfeng Wang, Bingsheng Zhou*, 2016. Enhanced Bioconcentration of Bisphenol A in the Presence of Nano-TiO2 Can Lead to Adverse Reproductive Outcomes in Zebrafish. Environ Sci &Technol 50, 1005-1013.
                    
        20.   Biran Zhu, Qiangwei Wang, Xiongjie Shi, Yongyong Guo, Tao Xu, Bingsheng Zhou*, 2016. Effect of combined exposure to lead and decabromodiphenyl ether on neurodevelopment of zebrafish larvae. Chemosphere 144, 1646-1654. 
                    
        21.   Zhou B*, 2015. Adverse outcome pathway: Framework, application, and challenges in chemical risk assessment. Journal of Environmental Sciences 35, 191-193.
                    
        22.   Jianghuan Hua, Jian Han, Yongyong Guo, Bingsheng Zhou*, 2015.The progestin levonorgestrel affects sex differentiation in zebrafish at environmentally relevant concentrations. Aquatic Toxicology 166, 1-9. 
                    
        23.   Qiangwei Wang, Nelson Lok-Shun Lai, Xianfeng Wang, Yongyong Guo, Paul Kwan-Sing Lam, James Chung-Wah Lam*, Bingsheng Zhou*, 2015. Bioconcentration and Transfer of the Organophorous Flame Retardant 1,3-dichloro 2-propyl phosphate (TDCPP) Causes Thyroid Endocrine Disruption and Developmental Neurotoxicity in Zebrafish Larvae. Environ Sci &Technol 49, 5123–5132. 
                    
        24.   Yongyong Guo, Yuanjin Yang, Yong Gao, Xianfeng Wang, Bingsheng Zhou*, 2015. The impact of long term exposure to phthalic acid esters on reproduction in Chinese rare minnow (Gobiocypris rarus). Environmental Pollution 203, 130-136. 
                    
        25.   Qiangwei Wang, James CW Lam, Jian Han, Xianfeng Wang, Yongyong Guo, Paul KS Lam, Bingsheng Zhou*, 2015. Developmental exposure to the organophosphorus flame retardant Tris(1,3-dichloro-2-propyl) phosphate: estrogenic activity, endocrine disruption and reproductive effects on zebrafish. Aquatic Toxicology 160, 163–171. 
                    
        26.   Xianfeng Wang, Lihua Yang, Yuanyuan Wu, Changjiang Huang, Qiangwei Wang, Jian Han, Yongyong Guo, Xiongjie Shi, Bingsheng Zhou*, 2015. The developmental neurotoxicity of PBDEs: Effect of DE-71 on dopamine in zebrafish larvae. Environ Toxicol & Chem 34, 1119–1126. 
                    
        27.   Qi Fang, Xiongiie Shi, Liping Zhang, Qiangwei Wang, Xianfeng Wang, Yongyong Guo, Bingsheng Zhou*, 2015. Effect of titanium dioxide nanoparticles on the bioavailability, metabolism, and toxicity of pentachlorophenol in zebrafish larvae. Journal of Hazardous Materials 283, 897-904. 
                    
        28.   Qiangwei Wang, James Chung-Wah Lam, Yin-Chung Man, Nelson Lok-Shun Lai, Karen Ying Kwok, Yong yong Guo, Paul Kwan-Sing Lam, Bingsheng Zhou*, 2015. Bioconcentration, Metabolism and Neurotoxicity of the Organophorous Flame Retardant 1,3-dichloro 2-propyl phosphate (TDCPP) to Zebrafish. Aquatic Toxicology 158, 108-115. 
                    
        29.   Biran Zhu, Qiangwei Wang, Xianfeng Wang, Bingsheng Zhou*, 2014. Impact of co-exposure of lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae. Aquatic Toxicology 157, 186-195. 
                    
        30.   Jian Han, Qiangwei Wang, Xianfeng Wang, Yonggang Li, Sheng Wen, Shan Liu, Guangguo Ying, Yongyong Guo, Bingsheng Zhou*, 2014. Impact of the synthetic progestin megestrol acetate on zebrafish reproduction. Aquatic Toxicology 150, 66-72. 
                    
        31.   Liqin Yu, Chunsheng Liu, Qi Chen, Bingsheng Zhou*, 2014. Endocrine disruption and reproduction impairment in zebrafish after long-term exposure to DE-71. Environ Toxicol & Chem 33, 1354–1362. 
                    
        32.    Wang Q, Chen Q, Zhou P, Li W, Wang J, Huang C, Wang X, Lin K, Zhou B*, 2014. Bioconcentration and metabolism of BDE-209 in the presence of titanium dioxide nanoparticles and impact on the thyroid endocrine system and neuronal development in zebrafish larvae. Nanotoxicology 8 (S1), 196–207. 
                    
        33.    Guo Y, Zhou B*, 2013. Thyroid endocrine system disruption by pentachlorophenol: an in vitro and in vivo assay. Aquatic Toxicology 142–143, 138-145. 
                    
        34.    Wang X, Yang Y, Zhang L, Ma Y, Han J, Yang L, Zhou B*, 2013. Endocrine disruption by di-(2-ethylhexyl)-phthalate in Chinese rare minnow (Gobiocypris rarus). Environ Toxicol & Chem 32, 1846-1854. 
                    
        35.    Chen L, Huang Y, Huang C, Hu B, Hu C, Zhou B*, 2013. Acute exposure to DE-71 causes alterations in visual behavior in zebrafish larvae. Environ Toxicol & Chem 32, 1370-1375.
                    
        36.    Wang Q, Liang K, Liu J, Yang L, Guo Y, Liu C*, Zhou B*, 2013. Exposure of zebrafish embryos/larvae to TDCPP alters concentrations of thyroid hormones and transcriptions of genes involved in the hypothalamic-pituitary-thyroid axis. Aquatic Toxicology 126, 207-213. 
                    
        37.    Chen L, Huang C, Hu C, Ke Y, Yang L, Zhou B*, 2012. Acute exposure to DE-71: Effects on locomotor behavior and developmental neurotoxicity in zebrafish larvae. Environ Toxicol & Chem 31, 2338-2344. 
                    
        38.    Chen L, Yu K, Huang C, Yu L, Zhu B, PKS Lam, JCW Lam*, Zhou B*, 2012. Prenatal transfer of polybrominated diphenyl ethers (PBDEs) results in developmental neurotoxicity in zebrafish larvae. Environ Sci & Technol 46, 9727-9734.
                    
        39.    Ma Y, Han J, Guo Y, Lam PKS, Wu RSS, Giesy JP, Zhang X, Zhou B*, 2012. Disruption of endocrine function in in vitro H295R cell-based and in in vivo assay in zebrafish by 2,4-dichlorophenol. Aquatic Toxicology 106-107, 173-181.
                    
        40.    Chen Q, Yu L, Yang L, Zhou B*, 2012. Bioconcentration and metabolism of decabromodiphenyl ether (BDE-209) result in thyroid endocrine disruption in zebrafish larvae. Aquatic Toxicology 110-111, 141-148. 
                    
        41.    Chen L, Hu C, Huang C, Wang Q, Wang X, Yang L, Zhou B*, 2012. Alterations in retinoid status after long-term exposure to PBDEs in zebrafish (Danio rerio). Aquatic Toxicology 120–121, 11–18.
                    
        42.    Ma Y, Han J, Guo Y, Lam PKS, Wu RSS, Giesy JP, Zhang X, Zhou B*, 2011. Modulation of steroidogenic gene expression and hormone synthesis in H295R cells exposed to PCP and TCP. Toxicology 282, 146–153.
                    
        43.    Yu L, Lam JCW, Guo Y, Wu RSS, Lam* PKS, Zhou B*, 2011. Parental transfer of PBDEs and thyroid endocrine disruption in zebrafish. Environ Sci & Technol 45, 10652–10659. 
                    
        44.    Liu C, Zhang X, Deng J, Hecker M, AL-Khedhairy A, Giesy JP, Zhou B*, 2011. Effects of prochloraz or propylthiouracil on the cross-talk between the HPG, HPA and HPT Axes in zebrafish. Environ Sci & Technol 45, 769–775. 
                    
        45.    Liu C, Zhang X*, Chang H, Jones P, Wiseman S, Naile J, Hecker M, Giesy JP, Zhou B*, 2010. Effects of fluorotelomer alcohol 8:2 FTOH on steroidogenesis in H295R cells: Targeting the cAMP signaling cascade. Toxicology & Applied Pharmacology 247, 222-228. 
                    
        46.    Shi X, Zhou B*, 2010. The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos. Toxicological Sciences 115, 391 – 400. 
                    
        47.    Yu L, Deng J, Shi X, Liu C, Yu K, Zhou B*, 2010. Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic–pituitary–thyroid axis of zebrafish larvae. Aquatic Toxicology 97, 226-233. 
                    
        48.   Liu C, Deng J, Yu L, Ramesh M, Zhou B*, 2010. Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 fluorotelomer alcohol. Aquatic Toxicology 96, 70-76. 
                    
        49.   Deng J, Liu C, Yu L, Zhou B*, 2010. Chronic exposure to environmental levels of   tribromophenol impairs zebrafish reproduction. Toxicology & Applied Pharmacology 243, 87-95. 
                    
        50.    Shi X, Yeung LWY, Lam PKS, Wu RSS, Zhou B*, 2009. Protein Profiles in Zebrafish (Danio rerio) Embryos Exposed to PFOS. Toxicological Sciences 110, 334-340.  
                    
        51.    Deng J, Yu L, Liu C, Yu K, Shi X, Yeung L, Lam PKS, Wu RSS, Zhou B*, 2009. Hexabromocyclododecane-induced developmental toxicity and apoptosis in zebrafish embryos. Aquatic Toxicology 93, 29-36.
                    
        52.    Liu C, Yu L, Deng J, Lam PKS, Wu RSS, Zhou B*, 2009. Waterborne exposure to fluorotelomer alcohol 6:2 FTOH alters plasma sex hormone and gene transcription in the hypothalamic–pituitary–gonadal (HPG) axis of zebrafish. Aquatic Toxicology 93, 131-137. 
                    
        53.    Du Y, Shi X, Liu C, Yu K, Zhou B*, 2009. Chronic effects of waterborne PFOS exposure on growth, survival and hepatotoxicity in zebrafish: a partial life-cycle test. Chemosphere 74, 723-729. 
                    
        54.    Yu K, He Y, Yeung LWY, Lam PKS, Wu RSS, Zhou B*, 2008. DE-71-induced apoptosis involving intracellular calcium and the Bax-mitochondria-caspase protease pathway in human neuroblastoma cells in vitro. Toxicological Sciences 104, 341-351. 
                    
        55.    Shi X, Du Y, Lam PKS, Wu RSS, Zhou B*, 2008. Developmental toxicity and alteration of gene expression in zebrafish embryos exposed to PFOS. Toxicology & Applied Pharmacology 230, 23-32. 
                    
        56.    Liu C, Du Y, Zhou B*, 2007. Evaluation of estrogenic activities and mechanism of action of perfluorinated chemicals determined by vitellogenin induction in primary cultured tilapia hepatocytes. Aquatic Toxicology 85, 267-277.
                    
        57.    Liu C, Yu K, Shi X, Wang J, Lam PKS, Wu RSS, Zhou B*, 2007. Induction of oxidative stress and apoptosis by PFOS and PFOA in primary cultured hepatocytes of freshwater tilapia (Oreochromis niloticus). Aquatic Toxicology 82, 135-143.
                    
        58.    Zhou B*, Liu C, Wang J, Lam PKS, Wu RSS, 2006. Primary cultured cells as sensitive in vitro model for assessment of toxicants-comparison to hepatocytes and gill epithelia. Aquatic Toxicology 80, 109-118.
                    
         
                    
        專(zhuān)利：
                    
         
                    論著(zhù)：周炳升，楊麗華，劉春生：“持久性有機污染物的內分泌干擾效應”?？茖W(xué)出版社，2018。        		        
            
        獲獎及榮譽(yù)
                    
                                
        2011年獲中國科學(xué)院優(yōu)秀研究生導師獎
                    
        2012年獲中國科學(xué)院朱李月華優(yōu)秀教師獎
                    
        2013年獲中國科學(xué)院優(yōu)秀研究生指導教師獎
                    
        2015年獲政府特殊津貼
                    
        2019年獲教育部高?？茖W(xué)研究?jì)?yōu)秀成果獎（二等）（林群聲、林忠華、周炳升、呂綺霞、陳聯(lián)國）。“新興有機污染物在環(huán)境介質(zhì)中的賦存、富集與生物毒性。
                            		        
            
        社會(huì )任職
                    
                                
        中國化學(xué)會(huì )環(huán)境化學(xué)專(zhuān)業(yè)委員會(huì )委員
                    
        中國毒理學(xué)會(huì )分析毒理專(zhuān)業(yè)委員會(huì )委員
                    
        Aquatic Toxicology, Chemosphere, Journal of Environmental Sciences, 生態(tài)毒理學(xué)報、水生生物學(xué)報，環(huán)境化學(xué)，編委。
                            		        
            
        指導研究生情況
                    
                                
        研究生獲獎：
                    
        1. 2013年度和2016年度，劉春生、王薔薇獲中國科學(xué)院優(yōu)秀博士論文獎；
                    
        2. 2012年度和2015年度，馬彥博、王薔薇獲2012和2015年度博士研究生國家獎學(xué)金；孫玉苗獲2020年度碩士研究生國家獎學(xué)金。