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1982.9-1986.7 武漢大學(xué) 微生物專(zhuān)業(yè) 本科

1986.9-1989.7 中國科學(xué)院水生生物研究所 水生生物學(xué)專(zhuān)業(yè) 碩士

1994.8-1999.5 新加坡國立大學(xué) 動(dòng)物學(xué)專(zhuān)業(yè) 博士

1989.7-1994.6 中國科學(xué)院水生生物研究所  助理研究員

1999.5-2003.4 Case Western Reserve University（USA）  博士后

2003.5-2005.4 University of Pennsylvania (USA)  博士后

2005.5至今 中國科學(xué)院水生生物研究所  研究員

水產(chǎn)養殖（碩士生，博士生）

自2005年回國組建學(xué)科組以來(lái)，主要通過(guò)轉基因、基因編輯等技術(shù)，圍繞鯉科魚(yú)類(lèi)生長(cháng)代謝和繁育的內分泌調控、優(yōu)良等位變異的分子標記輔助育種等方面開(kāi)展研究，通過(guò)基因編輯技術(shù)，率先構建了3種單基因敲除的魚(yú)類(lèi)生長(cháng)模型，發(fā)現促進(jìn)魚(yú)類(lèi)生長(cháng)的2種內分泌調控方式：1）提升脂肪利用能力，為個(gè)體生長(cháng)期提供能量，可促進(jìn)魚(yú)類(lèi)生長(cháng)；2）鈍化魚(yú)類(lèi)應激反應，降低基礎運動(dòng)和代謝率，可促進(jìn)魚(yú)類(lèi)生長(cháng)。近期也通過(guò)基因編輯技術(shù)實(shí)現了黃河鯉的雄、雌單性性別穩定遺傳群體的構建，獲得的全雌黃河鯉群體養殖可較普通性別混養群體提升產(chǎn)量約30%。已在Nat. Med.、PNAS、Cell Reports、eLife、Sci Bull.、Redox Biol.、Engineering、Sci China?Life Sci.、J Mol. Cell. Biol.、Human Mol. Genetics、Mol. Cell. Biol.、Endocrinology、Biol.Reprod.、J. Biol. Chem.等重要國際學(xué)術(shù)刊物發(fā)表第一或通訊作者文章50余篇，其引用超過(guò)1400余次。

2010年獲得國家自然科學(xué)基金委杰出青年基金資助，2014年領(lǐng)銜“魚(yú)類(lèi)生物學(xué)及漁業(yè)生物技術(shù)研究創(chuàng )新團隊”入選科技部重點(diǎn)領(lǐng)域創(chuàng )新團隊，2016年入選中組部“萬(wàn)人計劃科技創(chuàng )新領(lǐng)軍人才”。曾主持多個(gè)國家973項目課題、國家自然科學(xué)基金委重點(diǎn)項目等，現主持有“藍色糧倉”科技專(zhuān)項 “水產(chǎn)養殖生物性別和發(fā)育的分子基礎與調控機制”項目等科研項目。

代表性論文：

1. Zhai G, Shu T, Yu G, Tang H, Shi C, Jia J, Lou Q, Dai X, Jin X, He J, Xiao W, Liu X, Yin Z*. 2022. Augmentation of progestin signaling rescues testis organization and spermatogenesis in zebrafish with the depletion of androgen signaling. eLife, 11:e66118.

2. Huang J, Shi C, Gao Y, Su J, Shu Y, Zeng N, Zhai G, Jin X, Han D, He J, Lou Q*, Yin Z*. 2021. Heterozygous depletion of pik3r1 improves growth and feed conversion efficiency in Gibel carp (Carassius gibelio). Aquaculture. 545:737207. DOI: 10.1016/j.aquaculture.2021.737207.

3. Shi, XT., Ye, C., Qin, XF., Zhou, LL., Xia, CH., Cai, TY., Xie, YY., Yin, Z.*, Hu, GF.* 2021. Novel pituitary actions of TAC4 gene products in teleost. International Journal of Molecular Science. In press

4. Xia, CH., Qin, XF., Zhou, LL., Shi, XT., Cai, XT., Xie, YY., Li, W., Du, RX., Ouyang，Y., Yin, Z.*, Hu, GF.* 2021. Reproductive regulation of PrRPs in teleost: the link between feeding and reproduction. Frontier in Endocrinology. In press.

5. Song, J., Lu, Y., Cheng, XX., Shi, C., Lou, QY., Jin, X., He, JY., Zhai, G*., Yin, Z.* 2021. Functions of the Thyroid-Stimulating Hormone on key developmental features revealed in a series of zebrafish dyshormonogenesis models. Cells. 10(8); DOI10.3390/cells10081984.

6. Xu, S., Zhou, L., Chen, X., Hu, Q., Shi, X., Xia, C., Zhang, H., Jia, J., Yin, Z.*, Hu, GF.* 2021. Novel pituitary actions of NKB for anorectic peptides regulation in grass carp. Aquaculture. 531: https://doi.org/10.1016/j.aquaculture.2020.735857.

7. Shi, C., Lou, Q., Fu, B., Jin, J., Huang, J., Lu, Y., Zhai, G., Xie, S., Tong, J., Gui, G., Yin, Z.* 2021. Genomic polymorphisms at the crhr2 locus improve feed conversion efficiency through alleviation of hypothalamus-pituitary-interrenal axis activity in Gibel carp (Carassius gibelio). SCIENCE CHINA Life Sciences. published online on Apr 30, 2021.

8. Zhai, G., Shu, T., Chen, K., Lou, Q., Jia, Y., Huang, J., Shi, C., Jin, X., He, J., Jiang, D., Qian, X., Hu, W., Yin, Z.* 2021. Successful Production of an All-female Common Carp (Cyprinus carpio L.) Population Using cyp17a1-deficient Neomale Carp. Engineering. 8,181-189.

9. Dai, X., Cheng, X., Huang, J., Gao, Y., Wang, D., Feng, Z., Zhai, G., Lou, Q., He, J., Wang, Z*., Yin, Z.* 2021. Rbm46, a novel germ cell specific factor, modulates meiotic progression and spermatogenesis. Biology of Reproduction. Published ahead print.

10. Shi, X., Guan, K., Peng, X., Xu, B., Zhou, X., Wang, S., Xu, S., Zheng, M., Wan, X., Guan, W., Su, K., Ye, M., Gao, X.*, Yin, Z.*, Li, X.*. 2021. Ghrelin Modulate Neuron Formation and Attention Deficit Hyperactivity Disorder-like Behaviors: From Animals to Human Models. Brian, Behavior, and Immunity. Available online 4 Jan.2021.

11. Shi, C., Lu, Y., Zhai, G., Huang, J., Shang, G., Lou, Q., Li, D., Jin, X., He, J., Du, Z., Gui, J., Yin, Z.* 2020. Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity. Journal of Molecular Cell Biology. 12(4): 291-304.

12. Luo, J., Zhang, X., He, S., Lou, Q., Zhai, G., Shi, C., Yin, Z.*, Zheng, F.* 2020. Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish. Redox Biology. Vol: 28 UNSP 101355

13. Shang G., Peng, X., Ji, C., Zhai, G., Ruan, Y., Lou, Q., Jin, X., He, J., Wang, H., Yin Z.* 2019. Steroidogenic acute regulatory protein and luteinizing hormone are required for normal ovarian steroidogenesis and oocyte maturation in zebrafish. Biology of Reproduction. 101(4):760-770.

14. Shu, T., Shu, Y., Gao, Y., Jin, X., He, J., Zhai, G., Yin, Z.* 2018. Depletion of Tissue-Specific Ion Transporters Causes Differential Expression of PRL Targets in Response to Increased Levels of Endogenous PRL. Frontiers in Endocrinology. Vol. 9: fendo. 2018.00683

15. Zhai, G., Shu, T., Xia, Y., Lu, Y., Shang, G., Jin, X., He, J., Nie, P., Yin, Z.* 2018. Characterization of the sexual traits development in the cyp17a1-deficient zebrafish. Endocrinology. 159(10): 3549-3562.（雜志年度top10%高被引文章）

16. Zhai, G., Song, J., Shu, T., Yan, J., Jin, X., He, J., Yin, Z.* 2017. LRH-1 sense signaling form phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/β-catenin signaling in zebrafish. Journal of Genetics and Genomics. 44(6): 307-318. （封面文章）

17. Dai X., Shu, Y., Lou, Q., Tian, Q., Zhai, G., Song, J., Lu, S., Yu, H., He, J., Yin, Z.* 2017. Tdrd12 is essential for germ cell development and maintenance in zebrafish. International Journal of Molecular Sciences. 18: (6):1127. 

18. Peng, X., Shang, G., Wang, W., Chen, X., Lou, Q., Zhai, G., Li, D., Du, Z., Ye, Y., Jin, X., He, J., Zhang, Y., Yin, Z.* 2017. Fatty acid oxidation in zebrafish adipose tissue is promoted by 1α,25(OH)2D3. Cell Reports. 19(7): 1444-1455. （國際維生素D學(xué)會(huì )年會(huì )點(diǎn)評的2017-2018年間最具影響的12篇文章）

19. Zhai, G., Shu, T., Xia, Y., Jin, X., He, J., Yin, Z.* 2017. Androgen signaling regulates the transcription of anti-Müllerian hormone via synergy with SRY-Related Protein SOX9A. Chinese Sciences Bulletin. 62(3):197-203.

20. Gao, Y., Dai, Z., Shi, C., Zhai, G., Jin, X., He, J., Lou, Q.*, Yin, Z.* 2016. Depletion of Myostatin b Promotes somatic Growth and Lipid Metabolism in Zebrafish. Frontiers in Endocrinology. 7: 10.3389/ fendo.2016.00088

21. Dai, X., Zhang, W., Zhuo, Z., He, J., Yin, Z.* 2015. Neuroendocrine regulation of somatic growth in fishes (review). Science China. Life Sciences. 58: 137-147.

22. He, W., Dai, X., Chen, X., He, J., Yin, Z.* 2014. Zebrafish Pituitary Gene Expression Before and After Sexual Maturation. Journal of Endocrinology. 221(3):429-440.

23. Li, D., Lou, Q., Zhai, G., Peng, X., Cheng, X., Dai, X., Zhuo, Z., Shang, G., Jin, X., Chen, X., Han, D., He, J., Yin, Z.* 2014. Hyperplasia and Cellularity Changes in IGF-1-Overexpressing Skeletal Muscle of Crucian Carp. Endocrinology. 155 (6)：2199-2212.

24. Zhai, G., Gu, Q., He, J., Lou, Q., Chen, X., Jin, X., Bi, E*., Yin, Z.* 2014. Sept6 is required for ciliogenesis in Kupffer’s vesicle, pronephros and neural tube during early embryonic development. Molecular and Cellular Biology. 34(7): 1310-1321.

25. Mei, Y., Yin, N., Jin, X., He, J., Yin, Z.* 2013. The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation. Endocrinology. 154 (12):4640-4649.

26. Chen, D., Li, L., Tu, X., Yin, Z.*, Wang, Q.* 2012. Functional characterization of Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation and angiogenesis during embryogenesis. Human Molecular Genetics. 22 (5)：963-976.

27. Jiang, N., Jin, X., He, J., Yin, Z.* 2012. The roles of follistatin1 in regulation of zebrafish fecundity and sexual differentiation. Biology of Reproduction. 87(3)：54.1-8.

28. Ji, C., Jin, X., He, J., Yin, Z.* 2012. Use of TSHβ:EGFP transgenic zebrafish as a rapid in vivo model for assessing thyroid-disrupting chemicals. Toxicology and Applied Pharmacology. 262(2)：149-155.

29. Lou, Q., He, J., Hu, L., Yin, Z.* 2012. Role of lbx2 in the noncanonical Wnt signaling pathway for convergence and extension movements and hypaxial myogenesis in zebrafish. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1823(5): 1024-1032. (通訊作者).

30. Sun, L., Xu, W., He, J., Yin, Z.* 2010. In vivo alternative assessment of the chemicals that interferre with anterior pituitary POMC expression and interregnal steroidogenesis in POMC:EGFP transgenic zebrafish. Toxicology and Applied Pharmacology. 248(3): 217-225.（

31. Li, X., He, JY., Hu, W., Yin, Z.* 2009. The essential role of endogenous ghrelin in growth hormone expression during zebrafish adenohypophysis development. Endocrinology. 150(6): 2767-2774.

32. Ma, L., Li, D., Wang, J., He, J., Yin, Z.* 2009. Effects of Adrenergic Agonists on the Extrahepatic Expression of Vitellogenin Ao1 in Heart and Brain of the Chinese Rare Minnow (Gobiocypris rarus). Aquatic Toxicology. 91 (1): 19-25.

33. Trivedi, CM.*, Luo, Y*., Yin, Z.*, Zhang, M., Zhu, W., Wang, T., Floss, T., Goettlicher, M., Noppinger, PR., Wurst, W., Ferrari, VA., Abrams, CS., Gruber, PJ., Epstein, JA. (2007). HDAC2 regulates the cardiac fetal gene program and hypertrophic responsiveness by modulating GSK3?. Nature Medicine. 13(3): 324-331. (*等同第一作者).

34. . Yin, Z.*, Gonzales, L*., Kolla, V., Rath, N., Zhang, Y., Lu, MM., Kimura, S., Ballard, PL., Beers, MF., Epstein, JA. & Morrisey, EE. (2006). Hop functions downstream of Nkx2.1 and Gata6 to mediate HDAC-dependent negative regulation of pulmonary gene expression. Am. J. Physiol. Lung Cell Mol. Physiol. 291：L191-199. (*等同第一作者)

35. Yin, Z., Jeni Haynie, Bryan R. Williams and Yu-Chung Yang. (2003). C114 is a novel IL-11-inducible nuclear dsRNA-binding protein that inhibits Protein Kinase R. J. Biol. Chem. 278, 22838-22845.

36. Yin, Z., Haynie, J., Yang, X., Han, B., Kiatchoosakun, S., Restivo, J., Yuan, S., Prabhakar, N. R., Herrup, K., Conlon, R. A., Hoit, B. D., Watanabe, M and Yu-Chung Yang. (2002) The essential role of Cited2, a negative regulator for HIF-1 in heart development and neurulation. Proc. Nat. Acad. Sci. USA. 99, 10488-10493.

出版專(zhuān)著(zhù)：

1. 殷戰，廖傳松，劉家壽等，2021年，《丹江口水庫增養殖容量與放養調控技術(shù)》，科學(xué)出版社。

2. 桂建芳，周莉，殷戰，胡煒，童金茍，孫永華，肖武漢，2021年，《水產(chǎn)遺傳育種學(xué)》，科學(xué)出版社

授權專(zhuān)利：

1. 殷戰;梅蕓;尹乃達;賀江燕。腎上腺素受體激動(dòng)劑誘導胚胎型珠蛋白表達及其用途。專(zhuān)利號CN101926998B，授權公告日：2013年9月3日。

2. 殷戰;石闖;童金茍;解綬啟;婁氣永;翟剛。一種促進(jìn)魚(yú)類(lèi)生長(cháng)性狀改良的方法。專(zhuān)利號：CN201910413299.6，授權公告日：2019年5月17日。

中國動(dòng)物學(xué)會(huì )斑馬魚(yú)分會(huì )、中國動(dòng)物學(xué)會(huì )比較內分泌學(xué)會(huì )理事

Engineering、Frontiers in Endocrinology、PLoS ONE等期刊編委

已指導畢業(yè)碩士、博士畢業(yè)生近20名，多名學(xué)生獲中科院院長(cháng)獎學(xué)金優(yōu)秀獎等各類(lèi)院級、武漢分院級獎學(xué)金。

現指導在讀碩士、博士在讀研究生8名。

歡迎有生物學(xué)背景的考生報考。