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            中國科學(xué)院水生生物研究所歡迎您的來(lái)訪(fǎng)！
        
        
        
    
        

        

        
    
        
        
        
            
        
                
            
        
            
        
                
        
                    
                
        
            
        
        
        
    
        

        





        
    
        
        
        
            

        
        
        
        
            
        
                
                
                
        
					  
        
						  
        何舜平　研究員
        博士研究生
        
						  
        
							
        
								
        
							
        
							
        
								
        
                                    
        
                                            
                                              
        
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        簡(jiǎn)歷介紹：
         
        　　1962年12月2日出生，法國國家自然歷史博物館理學(xué)博士，中國科學(xué)院水生生物標本館館長(cháng)、中國科學(xué)院水生生物多樣性與保護重點(diǎn)實(shí)驗室主任、魚(yú)類(lèi)系統發(fā)育與生物地理學(xué)學(xué)科組責任研究員。中國動(dòng)物學(xué)會(huì )理事，湖北省暨武漢動(dòng)物學(xué)會(huì )理事長(cháng)。湖北省科協(xié)第六屆委員；任《中國動(dòng)物志》編委，以及《生物多樣性》，《動(dòng)物學(xué)研究》，《應用與環(huán)境生物學(xué)報》和《水生生物學(xué)報》編委。先后主持和承擔歐盟項目、國家自然科學(xué)重點(diǎn)基金、國家自然科學(xué)青年基金、國家863項目和973專(zhuān)題。 得到美國NSF有關(guān)生命之樹(shù)項目的資助開(kāi)展鯉形目系統發(fā)育研究。研究工作運用了生物技術(shù)、網(wǎng)絡(luò )和數字化技術(shù)相結合的手段，使魚(yú)類(lèi)系統學(xué)和生物地理學(xué)這一進(jìn)化生物學(xué)的前沿學(xué)科達到了較高的水平。使用多個(gè)基因序列數據重建鯉科和鲇形目魚(yú)類(lèi)的系統(Zhao, Duan et al. 2009; Fu, Chen et al. 2010; Chen, Zou et al. 2011; Fu and He 2012; Zou, Guo et al. 2012; Yang, Zou et al. 2013; Yang and He 2014)發(fā)育過(guò)程、提出了鯉科魚(yú)類(lèi)系統發(fā)育新的模式，保持了對鯉形目魚(yú)類(lèi)系統學(xué)研究在世界上的主導地位。最近，更得到中國科學(xué)院戰略性先導科技專(zhuān)項項目的資助，這對了解青藏高原和深海，這兩個(gè)極端環(huán)境的魚(yú)類(lèi)的基因組及其適應進(jìn)化，有重要意義。所在學(xué)科組在選題、使用的理論和方法上都達到國際先進(jìn)水平并直接參與國際競爭。尤其是在輻鰭魚(yú)類(lèi)的轉錄組、基因組、蛋白質(zhì)組等組學(xué)水平的研究，達到國際先進(jìn)水平。目前，已完成的有鰱魚(yú)、鳙魚(yú)的全基因組，正在進(jìn)行中的有塞內加爾多鰭魚(yú)、似鯰高原鰍、小眼高原鰍和黑斑原鮡全基因組。成功組裝、注釋了鰱、鳙魚(yú)的轉錄組和全基因組，找到鰱魚(yú)的鰱魚(yú)可以在水體中大量濾食有毒藍藻而不被MC所毒害的原因，可能與鰱魚(yú)體內的 GSH 合成通路中某些基因在進(jìn)化過(guò)程中受到了正向選擇有關(guān)，使其適應這種有毒的環(huán)境。塞內加爾多鰭魚(yú)，是淡水硬骨魚(yú)類(lèi)的原始類(lèi)型，是比較古老的輻鰭魚(yú)類(lèi)。多鰭魚(yú)的全基因組測序工作對了解整個(gè)輻鰭魚(yú)類(lèi)，甚至是四足類(lèi)的進(jìn)化有重要意義。而高原鰍和黑斑原鮡，這三種高原魚(yú)類(lèi)的基因組，有助于對高原這一低氧、低溫、高海拔的極端環(huán)境的魚(yú)類(lèi)適應性狀的解析。 
        　　主要創(chuàng  )新表現在：魚(yú)類(lèi)生物多樣性和標本信息的數字化管理，創(chuàng  )建了ChinaFishBase魚(yú)類(lèi)生物信息數據庫；運用分子系統學(xué)方法在鯉科魚(yú)類(lèi)系統發(fā)育研究方面取得重要成果，發(fā)現了鯉科魚(yú)類(lèi)系統發(fā)育新格局；運用生物地理學(xué)方法研究了魚(yú)類(lèi)物種分化與青藏高原隆升的關(guān)系；在國際上率先使用分子系統學(xué)方法對亞洲鲇類(lèi)及相關(guān)類(lèi)群開(kāi)展系統發(fā)育研究，率先對青藏高原這一高原極端環(huán)境魚(yú)類(lèi)的轉錄組和基因組進(jìn)行研究。研究成果為分子系統學(xué)與生物地理學(xué)學(xué)科的后續發(fā)展開(kāi)拓了新的領(lǐng)域。 
         
        研究方向：
        魚(yú)類(lèi)生物地理學(xué)；魚(yú)類(lèi)比較基因組學(xué)；生物信息學(xué)；魚(yú)類(lèi)系統發(fā)育 
         
         
        代表論著(zhù)：
         
        　　[1]  Yang, L. and S. He (2014). "A bioinformatics-based update on microRNAs and their targets in rainbow trout (Oncorhynchus mykiss)." Gene 533(1): 261-269. 
        　　[2]  Yang, L., M. Zou, et al. (2013). "Genome-wide identification, characterization, and expression analysis of lineage-specific genes within zebrafish." Bmc Genomics 14. 
        　　[3]  Tao, W., R. L. Mayden, et al. (2013). "Remarkable phylogenetic resolution of the most complex clade of Cyprinidae (Teleostei: Cypriniformes): A proof of concept of homology assessment and partitioning sequence data integrated with mixed model Bayesian analyses." Molecular Phylogenetics and Evolution 66(3): 603-616. 
        　　[4]  Tao, W., J. Yuan, et al. (2013). "Characterization of Gonadal Transcriptomes from Nile Tilapia (Oreochromis niloticus) Reveals Differentially Expressed Genes." Plos One 8(5). 
        　　[5]  Zou, M., B. Guo, et al. (2012). "Integrating multi-origin expression data improves the resolution of deep phylogeny of ray-finned fish (Actinopterygii)." Sci Rep 2. 
        　　[6]  Fu, B. and S. He (2012). "Transcriptome Analysis of Silver Carp (Hypophthalmichthys molitrix) by Paired-End RNA Sequencing." DNA Research 19(2): 131-142. 
        　　[7]  Chen, M., M. Zou, et al. (2011). "Evolutionary Patterns of RNA-Based Duplication in Non-Mammalian Chordates." Plos One 6(7). 
        　　[8]  Fu, B., M. Chen, et al. (2010). "The rapid generation of chimerical genes expanding protein diversity in zebrafish." Bmc Genomics 11. 
        　　[9]  Zhao, K., Z. Y. Duan, et al. (2009). "The youngest split in sympatric schizothoracine fish (Cyprinidae) is shaped by ecological adaptations in a Tibetan Plateau glacier lake." Mol Ecol 18(17): 3616-3628. 
        　　[10]  Guo, B.C., Tong, C.B., He, S.P., 2009. Sox genes evolution in closely related young tetraploid cyprinid fishes and their diploid relative. Gene 439, 102-112. 
        　　[11]  Li, Z., He, S., 2009. Relaxed purifying selection of rhodopsin gene within a Chinese endemic cavefish genus Sinocyclocheilus (Pisces: Cypriniformes). Hydrobiologia 624, 139-149. 
        　　[12]  Tong, C.B., Guo, B.C., He, S.P., 2009. Bead-probe complex capture a couple of SINE and LINE family from genomes of two closely related species of East Asian cyprinid directly using magnetic separation. BMC Genomics 10, -. 
        　　[13]   Duan, Z., Zhao, K., Peng, Z., Li, J., Diogo, R., He, S., Zhao, X., 2009. Comparative phylogeography of the Yellow River schizothoracine fishes (Cyprinidae): Vicariance, expansion, and recent coalescence in response to the Quaternary environmental upheaval in the Tibetan Plateau. Mol Phylogenet Evol. 
        　　[14]   Guo, B., Li, J., Tong, C., He, S., 2008. Cloning and sequence analysis of Sox genes in a tetraploid cyprinid fish, Tor douronensis. Chin Sci Bull 53, 1988-1995. 
        　　[15]   He, S., Gu, X., Mayden, R.L., Chen, W.-J., Conway, K.W., Chen, Y., 2008b. Phylogenetic position of the enigmatic genus Psilorhynchus (Ostariophysi: Cypriniformes): evidence from the mitochondrial genome. Mol Phylogenet Evol 47, 419-425. 
        　　[16]   He, S., Mayden, R.L., Wang, X., Wang, W., Tang, K.L., Chen, W.-J., Chen, Y., 2008c. Molecular phylogenetics of the family Cyprinidae (Actinopterygii: Cypriniformes) as evidenced by sequence variation in the first intron of S7 ribosomal protein-coding gene: Further evidence from a nuclear gene of the systematic chaos in the family. Mol Phylogenet Evol 46, 818-829. 
        　　[17]   Kong, X., Wang, X., Gan, X., Li, J., He, S., 2008. Molecular evolution of connective tissue growth factor in Cyprinidae (Teleostei : Cypriniformes). Progr Nat Sci 18, 155-160. 
        　　[18]   Li, J., Wang, X., Kong, X., Zhao, K., He, S., Mayden, R.L., 2008. Variation patterns of the mitochondrial 16S rRNA gene with secondary structure constraints and their application to phylogeny of cyprinine fishes (Teleostei: Cypriniformes). Mol Phylogenet Evol 47, 472-487. 
        　　[19]   Li, Z., Guo, B., Li, J., He, S., Chen, Y., 2008. Bayesian mixed models and divergence time estimation of Chinese cavefishes (Cyprinidae : Sinocyclocheilus). Chin Sci Bull 53, 2342-2352. 
        　　[20]   Mayden, R.L., Tang, K.L., Wood, R.M., Chen, W.-J., Agnew, M.K., Conway, K.W., Yang, L., Simons, A.M., Bart, H.L., Harris, P.M., Li, J., Wang, X., Saitoh, K., He, S., Liu, H., Chen, Y., Nishida, M., Miya, M., 2008. Inferring the Tree of Life of the order Cypriniformes, the earth's most diverse clade of freshwater fishes: Implications of varied taxon and character sampling. J Syst Evol 46, 424-438. 
        　　[21]   Sullivan, J.P., Peng, Z., Lundberg, J.G., Peng, J., He, S., 2008. Molecular evidence for diphyly of the Asian catfish family Amblycipitidae (Teleostei: Siluriformes) and exclusion of the South American Aspredinidae from Sisoroidea. Proc Acad Nat Sci Phila 157, 51-65. 
        　　[22]   Yang, L., He, S., 2008. Phylogeography of the freshwater catfish Hemibagrus guttatus (Siluriformes, Bagridae): Implications for South China biogeography and influence of sea-level changes. Mol Phylogenet Evol 49, 393-398. 
        　　[23]   Guo, X., He, S., Zhang, Y., 2007. Phylogenetic relationships of the Chinese sisorid catfishes: a nuclear intron versus mitochondrial gene approach. Hydrobiologia 579, 55-68. 
        　　[24]   Han, Y., He, S., Chen, Y., 2007. Identification of novel SINEs from Cyprinidae and their evolutionary significance. Progr Nat Sci 17, 270-279. 
        　　[25]   Huang, S., He, S., Peng, Z., Zhao, K., Zhao, E., 2007. Molecular phylogeography of endangered sharp-snouted pitviper (Deinagkistrodon acutus; Reptilia, Viperidae) in Mainland China. Mol Phylogenet Evol 44, 942-952. 
        　　[26]   Kong, X., Wang, X., Gan, X., He, S., 2007. The c-myc coding DNA sequences of cyprinids (Teleostei: Cypriniformes): Implications for phylogeny. Chin Sci Bull 52, 1491-1500. 
        　　[27]    Kong, X., Wang, X., Gan, X., Li, J., He, S., 2007. Phylogenetic relationships of Cyprinidae (Teleostei: Cypriniformes) inferred from the partial S6K1 gene sequences and implication of indel sites in intron 1. Sci China C Life Sci 50, 780-788. 
        　　[28]    Ku, X., Peng, Z., Diogo, R., He, S., 2007. MtDNA phylogeny provides evidence of generic polyphyleticism for East Asian bagrid catfishes. Hydrobiologia 579, 147-159. 
        　　[29]    Luo, J., Stadler, P.F., He, S., Meyer, A., 2007. PCR survey of hox genes in the goldfish Carassius auratus auratus. J Exp Zool Part B Mol Dev Evol 308, 250-258. 
        　　[30]    Mayden, R.L., Tang, K.L., Conway, K.W., Freyhof, J., Chamberlain, S., Haskins, M., Schneider, L., Sudkamp, M., Wood, R.M., Agnew, M., Bufalino, A., Sulaiman, Z., Miya, M., Saitoh, K., He, S., 2007. Phylogenetic relationships of Danio within the order Cypriniformes: a framework for comparative and evolutionary studies of a model species. J Exp Zool Part B Mol Dev Evol 308B, 642-654. 
        　　[31]    Peng, Z., Ludwig, A., Wang, D., Diogo, R., Wei, Q., He, S., 2007. Age and biogeography of major clades in sturgeons and paddlefishes (Pisces: Acipenseriformes). Mol Phylogenet Evol 42, 854-862. 
        　　[32]    Wang, L., He, S., Chen, Y., 2007. Identification of the Angel-related elements in cyprinid fishes and their phylogenetic implications. Progr Nat Sci 17, 168-171. 
        　　[33]    Wang, X., Li, J., He, S., 2007. Molecular evidence for the monophyly of East Asian groups of Cyprinidae (Teleostei: Cypriniformes) derived from the nuclear recombination activating gene 2 sequences. Mol Phylogenet Evol 42, 157-170. 
        　　[34]    Wang, X., Wang, J., He, S., Mayden, R.L., 2007. The complete mitochondrial genome of the Chinese hook snout carp Opsariichthys bidens (Actinopterygii: Cypriniformes) and an alternative pattern of mitogenomic evolution in vertebrate. Gene 399, 11-19. 
        　　[35]    Zhao, K., Duan, Z.Y., Yang, G.S., Peng, Z., He, S., Chen, Y., 2007. Origin of Gymnocypris przewalskii and phylogenetic history of Gymnocypris eckloni (Teleostei: Cyprinidae). Progr Nat Sci 17, 520-528. 
        　　[36]     Chen, J., Xie, Z., He, S., 2006. A taxonomic study of Oconnorella (Enchytraeidae, Oligochaeta) from Changbaishan Mountain, China. Zoological Science 23, 917-922. 
        　　[37]     Peng, Z., He, S., Wang, J., Wang, W., Diogo, R., 2006. Mitochondrial molecular clocks and the origin of the major Otocephalan clades (Pisces: Teleostei): A new insight. Gene 370, 113-124. 
        　　[38]     Peng, Z., Ho, S.Y.W., Zhang, Y., He, S., 2006. Uplift of the Tibetan plateau: Evidence from divergence times of glyptosternoid catfishes. Mol Phylogenet Evol 39, 568-572. 
        　　[39]     Peng, Z., Wang, J., He, S., 2006. The complete mitochondrial genome of the helmet catfish Cranoglanis bouderius (Siluriformes: Cranoglanididae) and the phylogeny of otophysan fishes. Gene 376, 290-297. 
        　　[40]     Xu, H.G., Ding, H., Li, M.Y., Qiang, S., Guo, J.Y., Han, Z.M., Huang, Z.G., Sun, H.Y., He, S.P., Wu, H.R., Wan, F.H., 2006. The distribution and economic losses of alien species invasion to China. Biol Invasions 8, 1495-1500. 
        　　[41]     Xu, H.G., Qiang, S., Han, Z.M., Guo, J.Y., Huang, Z.G., Sun, H.Y., He, S.P., Ding, H., Wu, H.R., Wan, F., 2006. The status and causes of alien species invasion in China. Biodivers Conserv 15, 2893-2904. 
        　　[42]     Yang, J., He, S., Freyhof, J., Witte, K., Liu, H., 2006. The Phylogenetic Relationships of the Gobioninae (Teleostei: Cyprinidae) Inferred from Mitochondrial Cytochrome b Gene Sequences. Hydrobiologia 553, 255-266. 
        　　[43]      Guo, X., He, S., Zhang, Y., 2005. Phylogeny and biogeography of Chinese sisorid catfishes re-examined using mitochondrial cytochrome b and 16S rRNA gene sequences. Mol Phylogenet Evol 35, 344-362. 
        　　[44]      He, S., Wang, D., Wang, W., Chen, D., Zhao, Q., Gong, W., 2005. Genetic diversity in the Yangtze finless porpoise by RAPD analysis. High Technology Letters 11, 207-210. 
        　　[45]      Li, J.B., Wang, X.Z., He, S.P., Chen, Y.Y., 2005. Phylogenetic studies of Chinese labeonine fishes (Teleostei: Cyprinidae) based on the mitochondrial 16S rRNA gene. Progr Nat Sci 15, 213-219. 
        　　[46]      Peng, Z.G., Zhang, Y.G., He, S.P., Chen, Y.Y., 2005. Phylogeny of chinese catfishes inferred from mitochondrial cytochrome b sequences. Acta Genet Sin 32, 145-154. 
        　　[47]       Son, Y.-M., He, S.-P., 2005. Cobitis zhejiangensis, a new species from the Ling River, China (Teleostei: Cobitidae) Korean Journal of Ichthyology 17, 236-240. 
        　　[48]       Zhao, K., Li, J.B., Yang, G.S., Duan, Z.Y., He, S.P., Chen, Y.Y., 2005. Molecular phylogenetics of Gymnocypris (Teleostei: Cyprinidae) in Lake Qinghai and adjacent drainages. Chin Sci Bull 50, 1325-1333. 
        　　[49]       Chen, Y., Wang, Y., He, S., Zhu, Z., 2004. Cloning and sequencing of the growth hormone gene of large yellow croaker and its phylogenetic significance. Biochem Genet 42, 365-375. 
        　　[50]       He, S., Liu, H., Chen, Y., Kuwahara, M., Nakajima, T., Zhong, Y., 2004. Molecular phylogenetic relationships of Eastern Asian Cyprinidae (Pisces: Cypriniformes) inferred from cytochrome b sequences. Sci China Ser C Life Sci 47, 130-138. 
        　　[51]       Peng, Z., He, S., Zhang, Y., 2004. Phylogenetic relationships of glyptosternoid fishes (Siluriformes: Sisoridae) inferred from mitochondrial cytochrome b gene sequences. Mol Phylogenet Evol 31, 979-987. 
        　　[52]       Sun, Y., Liu, S.Y., Zhao, G., He, S.P., Wu, Q.J., Taniguchi, N., Yu, Q.X., 2004. Genetic structure of Chinese sucker population Myxocyprinus asiaticus in the Yangtze River based on mitochondrial DNA marker. Fisheries Science 70, 412-420. 
        　　[53]       Wang, X., Liu, H., He, S., Chen, Y., 2004. Sequence analysis of cytochrome b gene indicates that East Asian group of cyprinid subfamily Leuciscinae (Teleostei : Cyprinidae) evolved independently. Progr Nat Sci 14, 132-137. 
        　　[54]       Wang, W., He, S.P., Chen, Y.Y., 2002. Mitochondrial d-loop sequence variation and phylogeny of gobiobotine fishes. Progr Nat Sci 12, 866-868. 
        　　[55]       Wang, X.Z., He, S.P., Chen, Y.Y., 2002. Sequence variations of the S7 ribosomal protein gene in primitive cyprinid fishes: Implication on phylogenetic analysis. Chin Sci Bull 47, 1638-1643. 
        　　[56]      Zhang, E., He, S.P., Chen, Y.Y., 2002. Revision of the cyprinid genus Placocheilus Wu, 1977 in China, with description of a new species from Yunnan. Hydrobiologia 487, 207-217. 
        　　[57]      He, S.P., Cao, W.X., Chen, Y.Y., 2001. The uplift of Qinghai-Xizang (Tibet) Plateau and the vicariance speciation of glyptosternoid fishes (Siluriformes : Sisoridae). Sci China Ser C Life Sci 44, 644-651. 
        　　[58]      He, S.P., Chen, Y.Y., Tsuneo, N., 2001. Sequences of cytochrome b gene for primitive cyprinid fishes in East Asia and their phylogenetic concerning. Chin Sci Bull 46, 661-665.