導師隊伍
| 職 稱(chēng)： | 研究員 |
|---|---|
| 學(xué) 歷： | 博士研究生 |
| 聯(lián)系方式： | 86-27-68780051 |
| 電子郵件： | huwei#ihb.ac.cn(請改#為@) |
| 辦 公 室： | 2號實(shí)驗樓905 |
| 個(gè)人網(wǎng)頁(yè)： |
簡(jiǎn)歷介紹：
胡煒，男，博士，研究員，博士生導師，魚(yú)類(lèi)基因工程學(xué)科組組長(cháng)，副所長(cháng)。國家自然科學(xué)基金創(chuàng )新研究群體學(xué)術(shù)帶頭人，湖北省自然科學(xué)基金創(chuàng )新群體學(xué)術(shù)帶頭人。先后在南開(kāi)大學(xué)和中國科學(xué)院研究生院獲學(xué)士、碩士和博士學(xué)位。國家水產(chǎn)原種和良種審定委員會(huì )委員，國家農業(yè)轉基因生物安全委員會(huì )委員，國家藍色糧倉科技創(chuàng )新重點(diǎn)專(zhuān)項總體專(zhuān)家組成員，中國水產(chǎn)學(xué)會(huì )淡水養殖分會(huì )副主任委員、水產(chǎn)生物技術(shù)專(zhuān)業(yè)委員會(huì )委員，中國動(dòng)物學(xué)會(huì )比較內分泌分會(huì )理事。Comparative Biochemistry and Physiology、Frontiers in Endocrinology、水生生物學(xué)報、遺傳、農業(yè)生物技術(shù)學(xué)報、中國農業(yè)科技導報和水產(chǎn)學(xué)報等學(xué)術(shù)期刊編委。
主要從事魚(yú)類(lèi)生殖發(fā)育調控、魚(yú)類(lèi)分子遺傳育種和克隆胚胎再程序化機制等研究。先后主持國家杰出青年基金、國家自然科學(xué)基金重點(diǎn)項目、國家重點(diǎn)研發(fā)計劃項目、863項目和湖北省杰出青年基金、湖北省創(chuàng )新研究群體等項目。發(fā)現脊椎動(dòng)物生殖軸的核心信號GnRH3具有調控性別分化的新功能，中樞神經(jīng)系統中最主要的抑制性神經(jīng)遞質(zhì)GABA對魚(yú)類(lèi)生殖具有雙重調控作用，揭示了魚(yú)類(lèi)生殖軸中重要信號分子在脊椎動(dòng)物雌雄生殖中的不同功能及調控性腺發(fā)育的機理，發(fā)現了魚(yú)類(lèi)生殖軸與生長(cháng)軸間新的信號調控通路，發(fā)現魚(yú)類(lèi)配子成熟需要RNA的m6A甲基化修飾，合作發(fā)現神經(jīng)內分泌激素SN在魚(yú)類(lèi)生殖、生殖行為及神經(jīng)血管發(fā)育中的新功能。創(chuàng )建了魚(yú)類(lèi)育性可控的生殖開(kāi)關(guān)新策略，培育出超雄鯉、偽雄鯉和偽雌鯉，合作培育出具有優(yōu)良養殖性狀的冠鯉和生殖發(fā)育可控的吉鯉，全面系統地評價(jià)了冠鯉的生態(tài)安全。首次報道了低溶氧耐受魚(yú)的成功研制。建立了黃鱔、鯉、鱘等重要養殖魚(yú)類(lèi)高效特異的基因組編輯技術(shù)平臺，并有效運用于遺傳育種和基因功能研究。建立模式動(dòng)物斑馬魚(yú)的克隆技術(shù)，獲得斑馬魚(yú)體細胞再程序化機制及克隆胚發(fā)育機理研究的新發(fā)現。
在PNAS，Genetics，Endocrinology，Journal of Molecular Cell Biology，Biology of Reproduction，Marine Biotechnology，Aquaculture，中國科學(xué)和科學(xué)通報等學(xué)術(shù)期刊上發(fā)表SCI論文80余篇，其中封面論文4篇；參編國內外著(zhù)作5本。獲美國發(fā)明專(zhuān)利4項，獲中國發(fā)明專(zhuān)利6項。
研究方向：
魚(yú)類(lèi)基因工程與生殖發(fā)育調控
代表論著(zhù)：
代表性論文目錄：
1. Mitchell Kimberly, Zhang Wo Su, Lu Chunyu, Tao Binbin, Chen Lu, Hu Wei*, Trudeau Vance L*. Targeted mutation of secretogranin-2 disrupts sexual behavior and reproduction in zebrafish. PNAS, 2020, 117(23）:12772–12783.
2. Feng Ke, Cui Xuefan, Song Yanlong, Tao Binbin, Chen Ji, Wang Jing, Liu Shaojun, Sun Yonghua, Zhu Zuoyan, Trudeau Vance L. and Hu Wei*. Gnrh3 regulates PGC proliferation and sex differentiation in developing zebrafish. Endocrinology, 2020,161(1) :1-13. doi: 10.1210/endocr/bqz024
3. Xia Hui, Zhong Chengrong, Wu Xingxing, Chen Ji, Tao Binbin, Xia Xiaoqin, Shi Mijuan, Zhu Zuoyan, Trudeau Vance L. and Hu Wei*. Mettl3 mutation disrupts gamete maturation and reduces fertility in zebrafish. Genetics, 2018, 208（2）：729-743.（雜志推介）
4. Tao Binbin, Hu Hongling, Mitchell Kimberly, Chen Ji, Jia Haibo, Zhu Zuoyan, Trudeau Vance L.*, Hu Wei*. Secretogranin-II plays a critical role in zebrafish neurovascular modeling. Journal of Molecular Cell Biology, 2018, 10(5): 388–401. (cover paper)
5. Song Yanlong, Tao Binbin, Chen Ji, Jia Shaoting, Zhu Zuoyan, Trudeau Vance L., Hu Wei*. GABAergic Neurons and Their Modulatory Effects on GnRH3 in Zebrafish. Endocrinology, 2017, 158(4):874–886.
6. Song Yanlong, Chen Ji, Tao Binbin, Luo Daji, Zhu Zuoyan, Hu Wei*. Kisspeptin2 Regulates Hormone Expression in Female Zebrafish (Danio rerio) Pituitary. Molecular and Cellular Endocrinology, 2020, 513：doi.org/10.1016/j.mce.2020.110858
7. Jiang Mouyan, Jia Shaoting, Chen Ji, Chen Kuangxin, Ma Wenge, Wu Xingxing , Luo Hongrui, Li Yongming, Zhu Zuoyan, Hu Wei*. Timing of gonadal development and dimorphic expression of sex-related genes in gonads during early sex differentiation in the Yellow River carp. Aquaculture, 2020, 518: 734825
8. Luo Hongrui, Feng Ke, Chen Ji, Song Yanlong, Hou Mingxi, Jiang Yinjun, Jiang Mouyan, Li Yongming, Tao Binbin, Wang Yaping, Zhu Zuoyan, Hu Wei*. Telophase of the first cleavage is the key stage for optimally inducing mitotic gynogenesis in rice field eel (Monopterus albus), Aquaculture (2019), doi.org/10.1016/j.aquaculture.2020.735241
9. Chen Ji, Cao Mengxi, Zhang Aidi, Shi Mijuan, Tao Binbin, Li Yongming, Wang Yaping, Zhu Zuoyan, Trudeau Vance L.*, Hu Wei*. Growth hormone overexpression disrupts reproductive status through actions on leptin. Frontiers in Endocrinology, 2018, 9: DOI: 10.3389/fendo.2018.00131
10. Chen Ji, Wang Wei, Tian Zhaohui, Dong Ying, Dong Tian, Zhu Hua, Zhu Zuoyan , Hu Hongxia*, Hu Wei*. Efficient gene transfer and gene editing in sterlet (Acipenser ruthenus). Frontiers in Genetics, 2018, 9: DOI: 10.3389/fgene.2018.00117
11. Feng K, Luo H, Hou M, Li Y, Chen J, Zhu Z, Hu W*. Alternative splicing of GnRH2 and GnRH2-associated peptide plays roles in gonadal differentiation of the rice field eel, Monopterus albus. General and Comparative Endocrinology, 2018, 267: 9-17.
12. Hu Hongling, Tao Binbin, Chen Ji, Zhu Zuoyan, Hu Wei*. Fam60al as a novel factor involved in reprogramming of somatic cell nuclear transfer in zebrafish (Danio rerio). International Journal of Biological Sciences, 2018; 14(1):78-86.
13. Jiang Mouyan, Wu Xingxing, Chen Kuangxin, Luo Hongrui, Yu Wei, Jia Shaoting, Li Yongming, Wang Yufeng, Yang Pinhong, Zhu Zuoyan and Hu Wei*. Production of YY super-male and XY physiological female common carp for potential eradication of this invasive species. Journal of the World Aquaculture Society, DOI: 10.1111/jwas.12492.（世界水產(chǎn)學(xué)會(huì )2018年度最佳應用類(lèi)論文獎）
14. Luo Daji, Feng Ke, Zhu Zuoyan and Hu Wei*. Generating gene knockout Oryzias Latipes and Rice Field eel using TALENs method. Springer Protocols, Methods in Molecular Biology, Microinjection: Methods and Protocols. Humana Press, 2019, 489-506..
14. Feng Ke, Luo Hongrui, Li Yongming, Chen Ji, Wang Yaping, Sun Yonghua, Zhu Zuoyan and Hu Wei*, High efficient gene targeting in rice field eel Monopterus albus by transcription activator-like effector nucleases. Science Bulletin, 2017, 62:162-164.
15. Dillon F. Da Fonte1, Christopher J. Martyniuk, Lei Xing, Adrian Pelin, Nicolas Corradi, Wei Hu & Vance L. Trudeau. Secretoneurin A regulates neurogenic and infammatory transcriptional networks in goldfsh (Carassius auratus) radial glia. Scientific Reports, 7: 14930, DOI:10.1038/s41598-017-14930-8
16. 俞薇，曹夢(mèng)西，陳戟，賈少婷，李勇明，朱作言，胡煒*。鯉性腺GnRH-GtH旁分泌系統的發(fā)現及其在生長(cháng)/生殖調控中的作用，農業(yè)生物技術(shù)學(xué)報，2017, 25(9): 1516-1525.
17. 朱作言，胡煒，轉基因魚(yú)及其安全性?？茖W(xué)，2017，69（6）：25-27.
18. Chen Ji. Cui Xiaojuan, Jia Shaoting, Luo Daji, Cao Mengxi, Zhang Yunsheng, Hu Hongling, Huang Kaiyao, Zhu Zuoyan & Hu Wei*. Disruption of dmc1 produces abnormal sperm in medaka (Oryzias latipes). Scientific Reports, 2016, 6, 30912; doi: 10.1038/srep30912.
19. Mikwar M, Navarro-Martin L, Volkoff H, Hu Wei and Trudeau V.L. Stimulatory effect of the secretogranin-ll derived peptide secretoneurin on food intake and locomotion in female goldfish (Carassius auratus), Peptides, 2016 Apr;78:42-50.
20. Peng Wei, Cao Mengxi, Chen Ji, Li Yongming, Wang Yaping, Zhu Zuoyan, Hu Wei*. GnIH plays a negative role in regulating GtH expression in the common carp, Cyprinus carpio L. General and Comparative Endocrinology, 2016, 235 :18–28.
21. Shu Yuqin, Lou Qiyong, Dai Ziru, Dai Xiangyan, He Jiangyan, Hu Wei* & Yin Zhan*, The basal function of teleost prolactin as a key regulator on ion uptake identified with zebrafish knockout models. Scientific Reports, 2016, 6:18597, DOI: 10.1038/srep18597.
22. Zhu T. B, Zhang L. H, Zhang T. L, Wang Y. P, Hu W, Ring？ E. and Zhu Z. Y. .Effects of sustained predation by fast-growing transgenic common carp (Cyprinus carpio Linnaeus, 1758) on gastropods in artificial environments. J. Appl. Ichthyol. 2016; DOI: 10.1111/jai.13130
23. 胡煒*，朱作言。美國轉基因大西洋鮭產(chǎn)業(yè)化對我國的啟示。中國工程科學(xué)， 2016，18（3）：105-109。
24. Zhang Yunsheng, Chen Ji, Cui Xiaojuan, Luo Daji, Xia Hui, Dai Jun, Zhu Zuoyan, Hu Wei*. A controllable on-off strategy for the reproductive containment of fish. Scientific Reports, 2015,5,7614; DOI:10.1038/srep07614.
25. Song Yanlong, DuanXiaohai, Chen Ji, Zhu Zuoyan, Hu Wei*. The distribution of Kiss1- and Kiss2-positive neurones and their connections with GnRH3 neurones in the zebrafish brain. Journal of Neuroendocrinology, 2015, 27(3): 198–211. (cover paper)
26. Luo Daji, Liu Yun, Chen Ji, Xia Xiaoqin, Cao Mengxi, Cheng Bin, Wang Xuejuan, Gong Wuming, Qiu Chao, Zhang Yunsheng, Cheng Christopher Hon Ki, Zhu Zuoyan & Hu Wei*. Direct production of XYDMY？sex reversal female medaka (Oryzias latipes) by embryo microinjection of TALENs. Scientific Reports,5:14057, DOI: 10.1038/srep14057
27. Tang Haipei, Liu Yun, Luo Daji, Ogawa Satoshi, Yin Yike, Li Shuisheng, Zhang Yong, Hu Wei, Parhar Ishwar S, Lin Haoran, Liu Xiaochun, Cheng Christopher H.K.. The kiss/kissr systems are dispensable for zebrafish reproduction: evidence from gene knockout studies. Endocrinology, 2015, 156:589-599.
28. Chu Lianhe, Li Jianzhen, Liu Yun, Hu Wei*, Cheng Christopher H.K*..Targeted gene disruption in zebrafish reveals noncanonical functions of Lh signaling in reproduction. Molecular Endocrinology, 2014, 28(11):1785-95.
29. Cao Mengxi, Chen Ji, Peng Wei, Wang Yaping, Liao Lanjie, Li Yongming, Trudeau Vance L., Zhu Zuoyan, Hu Wei*. Effects of growth hormone over-expression on reproduction in the common carp Cyprinus carpio L. General and Comparative Endocrinology, 2014, 195:47-57.
30. Garcia-ReyeroNatàlia, Tingaud-SequeiraAngèle, Cao Mengxi, Zhu Zuoyan, Perkins Edward, Hu Wei. Endocrinology: Advances through omics and related technologies, General and Comparative Endocrinology, 2014, 203:262-273.(Invited review)
31. Liu Y, Luo D, Lei Y, Zhao H, Hu W*, Cheng HK*, A highly effective TALEN-mediated approach for targeted gene disruption in Xenopus tropicalis and zebrafish, Methods, 2014, 69: 58–66.
32. Qiu Chao, Cheng Bin, Zhang Yunsheng, Huang Rong, Liao Lanjie, Luo Daji, Hu Wei*, Wang Yaping*. Efficient Knockout of Transplanted Green Fluorescent Protein Gene in Medaka using TALENs. Marine Biotechnology. 2014, 16(6):674-83 (cover paper)
33. Zhong C, Song Y, Wang Y, Zhang T, Duan M, Li Y, Liao L, Zhu Z, Hu W*. Increased food intake in growth hormone-transgenic common carp (Cyprinus carpio L.) may be mediated by upregulating Agouti-related protein (AgRP). General and Comparative Endocrinology，2013，192, 81-88.
34. Chen Ji, Hu Wei* & Zhu ZuoYan. Progress in studies of fish reproductive development regulation. Chinese Science Bulletin, 2013,58:7-16. 陳戟，胡煒，朱作言，魚(yú)類(lèi)生殖發(fā)育調控研究進(jìn)展?？茖W(xué)通報，2013,58:103-114.
35. Lian Hao, Hu Wei, Huang Rong, Du Fukuan, Liao Lanjie, Zhu Zuoyan, Wang Yaping. Transgenic Common Carp Do Not Have the Ability to Expand Populations. plos one, 2013, 8(6): e65506.
36. Liu Yun, Luo Daji, Zhao Hui, Zhu Zuoyan, Hu Wei*, Cheng Christopher H. K*.. Inheritable and Precise Large Genomic Deletions of Non-Coding RNA Genes in Zebrafish Using TALENs. plos one, 2013, 8(10): e76387.
37. Zhong Chengrong, Song Yanlong, Wang Yaping, Li Yongming, Liao Lanjie, XieShouqi, Zhu Zuoyan, Hu Wei*. Growth hormone transgene effects on growth performance are inconsistent among offspring derived from different homozygous transgenic common carp (Cyprinus carpio L.). Aquaculture, 2012, 356–357: 404–411.
38. Cao Mengxi, DuanJundan, Cheng Nana, ZhongXueping, Wang Zequn, Hu Wei*, Zhao Haobin*. Sexually dimorphic and ontogenetic expression of dmrt1, cyp19a1a and cyp19a1b in Gobiocypris rarus. Comparative Biochemistry and Physiology, Part A, 2012, 162: 303–309.
39. Cao Mengxi, Yang Yuhui, Xu Hongyan, DuanJundan, Cheng Nana, Wang Jialin, Hu Wei, Zhao Haobin. Germ cell specific expression of Vasa in rare minnow, Gobiocypris rarus, Comparative Biochemistry and Physiology, Part A, 2012, 162:163–170.
40. Guan Bo, Ma Hong, Wang Yaping, Hu Yuanlei, Lin Zhongping, Zhu Zuoyan, Hu Wei*. Vitreoscilla Hemoglobin (VHb) Overexpression Increases Hypoxia Tolerance in Zebrafish (Danio rerio). Marine Biotechnology, 2011, 13（2）: 336-344. (cover paper)
41. Li Deliang, FU Cuizhang, Wang Yaping, Zhu Zuoyan, Hu Wei*. The hematological response to exhaustive exercise in ‘a(chǎn)ll-fish’ growth hormone transgenic common carp (Cyprinus carpio L.). Aquaculture, 2011,311:263-268.
42. Luo Daji, Hu Wei*, Chen Shangping, Zhu Zuoyan. Critical Developmental Stages For The Efficiency Of Somatic Cell Nuclear Transfer In Zebrafish. International Journal of Biological Sciences, 2011,7: 476-486.
43. Xu Jing, Huang Wei, ZhongChengrong, Luo Daji, Li Shuangfei, Zhu Zuoyan and Hu Wei*, Defining Global Gene Expression Changes of the Hypothalamic-Pituitary-Gonadal Axis in Female sGnRH-Antisense Transgenic Common Carp (Cyprinus carpio). plos one, 2011, 6(6): e21057.
44. Xu Zhuwei, Li Qi, Wang Yun, Song Chaojun, Zhang Tao, Chen Lihua, JiJianguo, Yang Angang, Zhu Zuoyan, Hu Wei*, Jin Boquan*. Production, characterization, and applications of mouse monoclonal antibodies against gonadotropin, somatolactin, and prolactin from common carp (Cyprinus carpio). General and Comparative Endocrinology, 2010, 167:373-378.
45. Tang Bin, Hu Wei*, Hao Jun and Zhu Zuoyan. Developmental expression of steroidogenic factor-1, cyp19a1a and cyp19a1b from common carp (Cyprinus carpio). General and Comparative Endocrinology, 2010,167:408-416.
46. Dai J, Cui X, Zhu Z, Hu W*. Non-Homologous End Joining Plays a Key Role in Transgene Concatemer Formation in Transgenic Zebrafish Embryos. International Journal of Biological Sciences, 2010; 6:756-768.
47. Duan M., Zhang T., Hu W*., Guan B., Wang Y., Li Z. & Zhu Z.. Increased mortality of “all-fish” growth hormone transgenic common carp (Cyprinus carpio L.) under a short-term risk of predation. Journal of Applied Ichthyology, 2010, 26:908–912.
48. Guan Bo, HU Wei*, ZHANG Tanglin, DUAN Ming, LI Deliang, WANG Yaping, Zhu Zuoyan. Acute and chronic un-ionized ammonia toxicity to ‘a(chǎn)ll-fish’ growth hormone transgenic common carp (Cyprinus carpio L.). Chinese Science Bulletin, 2010, 55: 4032-4036.
49. Hu Wei and Zhu Zuoyan*. Integration mechanisms of transgenes and population fitness of GH transgenic fish. Science in China Ser C-Life Sci, 2010, 53:401-408.
50. Luo Yu-Shan, Hu Wei*, Liu Xiao-Chun, Lin Hao-Ran, Zhu Zuo-Yan. Molecular cloning and mRNA expression pattern of Sox9 during sex reversal in orange-spotted grouper (Epinephelus coioides). Aquaculture, 2010, 306:322-328.
51. Luo D, Hu W*, Chen S, Xiao Y, Sun Y, Zhu Z. Identification of Differentially Expressed Genes Between Cloned and Zygote-Developing Zebrafish (Danio rerio) Embryos at the Dome Stage Using Suppression Subtractive Hybridization. Biology of Reproduction, 2009，80：674-684.
52. Guan B, Hu W*, Zhang T, Wang Y, Zhu Z. Metabolism traits of 'all-fish' growth hormone transgenic common carp (Cyprinus carpio L.). Aquaculture, 2008; 284: 217-223.
53. Hu Wei, Li Shuangfei, Tang Bin, Wang Yaping, Lin Haoran，Liu Xiaochun, Zou Jun & Zhu Zuoyan*. Antisense for gonadotropin-releasing hormone reduces gonadotropin synthesis and gonadal development in transgenic common carp (Cyprinus carpio). Aquaculture, 2007, 271: 498–506.
54. Hu Wei, Wang Yaping& Zhu Zuoyan*. Progress in the evaluation of transgenic fish for possible ecological risk and its containment strategies. Science in China Ser C-Life Sci. 2007, 50:573-579. 胡煒，汪亞平，朱作言。轉基因魚(yú)生態(tài)風(fēng)險評價(jià)及其對策研究進(jìn)展。中國科學(xué)C輯：（生命科學(xué)），2007,37:377-381。
55. Wang Yun, Hu Wei*, Liu Weiyi, Wang Yaping, Zhu Zuoyan. Identification and characterization of a novel alternative splicing transcript of gonadotropin alpha subunit in the common carp (Cyprinus Carpio). Journal of Fish Biology, 2007, 71: 1082–1094.
56. Hu Wei, Wang Yaping and Zhu Zuoyan*. Perspective of fish gonad manipulation for biotechnical applications. Chinese Science Bulletin, 2006,51(18):1-7. 胡煒，汪亞平，朱作言。魚(yú)類(lèi)性腺發(fā)育調控的生物技術(shù)前景分析?？茖W(xué)通報，2005,50:2689-2694.
57. Hu W, Wang Y, Chen S and Zhu Z*. Nuclear transplantation in different strains of zebrafish, Chinese Science Bulletin, 2002, 47(15):1277-1280.
發(fā)明專(zhuān)利目錄：
1. Hu Wei, Jiang Mouyan, Li Yongming, Tao Binbin, Chenji and Zhu Zuoyan. Method for production YY super-male and XY physiological female common carps. 2020年獲美國發(fā)明專(zhuān)利，專(zhuān)利號：US 10701907 B2。
2. Hu Wei, Zhang Yunsheng, Dai Jun and Zhu Zuoyan. Controllable on-off method for fish reproduction. United States Patent and Trademark Office, 2015年獲美國發(fā)明專(zhuān)利，專(zhuān)利號：US 9,187,764 B2
3. Hu Wei, Zhu Z, Ma H, Guan B, Lin Z, and Hu R. Recombinant gene which enhances the ability of fish to tolerate low dissolved oxygen stress and the use thereof. United States Patent and Trademark Office, 2013年獲美國發(fā)明專(zhuān)利，專(zhuān)利號：US8, 546, 644 B2.
4. Hu Wei, Zhu Zuoyan, Wang Yaping and Li Shuangfei. Method for preparing a sterile transgenic carp. United States Patent and Trademark Office, 2007年獲美國發(fā)明專(zhuān)利，專(zhuān)利號：US7,230,156B2.
5. 胡煒，馮科，陳戟，朱作言。一種黃鱔基因編輯的方法。2019年獲中國發(fā)明專(zhuān)利，專(zhuān)利號：ZL201610651812.1
6. 胡煒，蔣謀炎，李勇明，陶彬彬，陳戟，朱作言。一種超雄鯉魚(yú)和遺傳雄性而生理雌性鯉魚(yú)的制備方法。2018年獲中國發(fā)明專(zhuān)利授權，專(zhuān)利號：ZL201710315756.9
7. 胡煒，羅紅瑞，馮科，蔣謀炎，侯明喜，朱作言。一種控制黃鱔受精卵第一次卵裂的方法及其應用。申請號：201711265194.8，公開(kāi)號：107916250A。
8. 胡煒，湯斌，汪亞平，朱作言，一種雌性鯉魚(yú)性逆轉為雄性鯉魚(yú)的培育方法，2012年獲中國發(fā)明專(zhuān)利，專(zhuān)利號：ZL201110186519.X
9. 胡煒，張運生，戴軍，朱作言，一種控制魚(yú)類(lèi)生殖的方法。2013年獲中國發(fā)明專(zhuān)利，專(zhuān)利號：ZL201310049161.5
10. 胡煒，朱作言，汪亞平，黎雙飛。不育轉基因魚(yú)的制備方法，2007年獲中國發(fā)明專(zhuān)利授權，專(zhuān)利號：ZL031254551。
11. 胡煒，朱作言，黎雙飛，汪亞平。一種殼聚糖甲基睪酮緩釋藥條的制備方法，2007年獲中國發(fā)明專(zhuān)利授權，專(zhuān)利號：ZL200510018148.9。
12. 吳玉萍，朱作言，胡煒，徐安龍。魚(yú)類(lèi)基因原位修飾育種的方法，2006年獲中國發(fā)明專(zhuān)利授權，專(zhuān)利號：ZL200410015247.7