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1987.9-1991.6 湖北大學(xué) 生物系 生物專(zhuān)業(yè) 本科

1993.9-1996.6 中國科學(xué)院水生生物研究所 遺傳學(xué)專(zhuān)業(yè) 碩士

2000.9-2003.6 中國科學(xué)院水生生物研究所 遺傳學(xué)專(zhuān)業(yè) 博士

水產(chǎn)養殖（碩士生，博士生）

魚(yú)類(lèi)抗病毒感染免疫學(xué)

本實(shí)驗室主要聚焦魚(yú)類(lèi)響應病毒感染的天然免疫分子機理及應用。致力于挖掘魚(yú)類(lèi)響應病毒感染的相關(guān)基因，解析相關(guān)基因的功能、調控機制及信號通路，發(fā)現特異于魚(yú)類(lèi)物種的抗病毒感染免疫規律，尤其是魚(yú)類(lèi)干擾素介導的天然抗病毒免疫反應的分子機理，鑒定潛在應用于魚(yú)類(lèi)抗病育種實(shí)踐的關(guān)鍵分子。近期擬在三個(gè)方面開(kāi)展研究工作：抗病毒感染的分子機制及分子調控；抗病毒因子的功能及應用；脊椎動(dòng)物免疫系統發(fā)育及分子進(jìn)化。近5年來(lái)在Journal of Immunology、Frontiers in Immunology、PLoS Pathogens等刊物發(fā)表論文十多篇。

1.      2018.12-2022.12科技部重點(diǎn)研發(fā)計劃項目課題（淡水魚(yú)類(lèi)抗病與抗逆性狀形成的分子機理），760萬(wàn)元，主持

2.      2020.1-2023.12．國家自然科學(xué)基金面上項目（銀鯽a亞類(lèi)干擾素基因IFNa1轉錄成胞外和胞內干擾素兩個(gè)轉錄本的選擇性剪接機理及抗病毒機制），58萬(wàn)，主持

3.      2018.1-2021.12．國家自然科學(xué)基金面上項目（魚(yú)類(lèi)TRIM16家族基因TRIM16a負調控干擾素抗病毒免疫反應的功能研究），65萬(wàn)，主持

4.      2019.8-2024.8中國科學(xué)院戰略先導科技專(zhuān)項A類(lèi)子任務(wù)（鯉病毒感染響應的分子網(wǎng)絡(luò )1），108萬(wàn)，主持

5.      2020.8-2022.12武漢市科技計劃項目應用基礎前沿專(zhuān)項（新型負調控因子TRIM16L 應用于魚(yú)類(lèi)抗病育種的機制研究），50萬(wàn)，主持

本學(xué)科組聚焦魚(yú)類(lèi)干擾素介導的天然抗病毒免疫這個(gè)研究主題。在揭示魚(yú)類(lèi)存在與哺乳類(lèi)相對保守的天然免疫反應機制的基礎上，發(fā)現了一系列特異于魚(yú)類(lèi)的干擾素抗病毒免疫新機制：鑒定了一批魚(yú)類(lèi)特異的參與干擾素抗病毒免疫反應的基因如PKZ、IRF11、以及Gig1和Gig2新基因家族等，并揭示出由這些特異基因介導的天然抗病毒反應途徑和分子機理；發(fā)現魚(yú)類(lèi)特有基因家族finTRIM家族在不同魚(yú)類(lèi)物種中獨立擴增的進(jìn)化規律，對鯽特異的FTRCA1的功能研究，揭示出魚(yú)類(lèi)物種特異的干擾素抗病毒免疫反應新機制；發(fā)現魚(yú)類(lèi)病毒核酸識別受體LGP2在病毒感染早期發(fā)揮正調控而在病毒感染晚期轉向負調控、有別于哺乳類(lèi)的分子機制；發(fā)現魚(yú)類(lèi)干擾素通過(guò)調控自身表達放大干擾素反應的獨特機理；發(fā)現魚(yú)類(lèi)和哺乳類(lèi)獨立形成相似的干擾素反應調控機制網(wǎng)絡(luò )的趨同進(jìn)化規律；發(fā)現脊椎動(dòng)物的干擾素反應經(jīng)歷了一個(gè)由轉錄因子IRF3介導的、從粗放調控到精確調控的演化規律。

近年發(fā)表部分論文：

1.      Feng H, Zhang YB, Gui JF, Lemon SM, Yamane D. Interferon regulatory factor 1 (IRF1) and antipathogen innate immune responses. PLoS Pathog 2021, 17(1): e1009220

2.      Zhao X, Gong XY, Li YL, Dan C, Gui JF, Zhang YB^*. Characterization of DNA binding and nuclear retention identifies zebrafish-specific IRF11 as a positive regulator of IFN antiviral response. Journal of Immunology. 2020, 205 (1):237-250

3.      Wu CX, Zhang YB^* and Hu CY^*. PKZ, a Fish-Unique eIF2 Kinase Involved in Innate Immune Response. Front. Immunol. 2020,11:585.

4.      Xiong Y, Dan C, Ren F, Su Z, Zhang YB^*, Mei J^*. Proteomic profiling of yellow catfish (Pelteobagrus fulvidraco) skin mucus identifies differentially-expressed proteins in response to Edwardsiella ictaluri infection. Fish Shellfish Immunol. 2020;100:98-108.

5.      Zang ZX, Dan C, Zhou L, Zhang QY, Gui JF, Zhang YB^*. Function characterization and expression regulation of two different-sized 3’untranslated region-containing interferon genes from clone F of gibel carp Carassius auratus gibelio. Molecular Immunology, 2020,119:18–26.

6.      Li YL, Zhao X, Gong XY, Dan C, Gui JF, Zhang YB^*. Molecular identification and function characterization of four finTRIM genes from the immortal fish cell line, EPC. Developmental and Comparative Immunology, 2020, 113:103775.

7.      李依琳，張義兵^*。魚(yú)類(lèi)RLR介導的抗病毒免疫反應的泛素化修飾調控。水生生物學(xué)報。2020，44(5): 976 -988 doi: 10.7541/2020.113

8.      Song W, Zhang YB, Zhang XJ, Gui, JF. De Novo Transcriptome Assembly of Four Organs of Collichthys Lucidus and Identification of Genes Involved in Sex Determination and Reproduction. PLoS One. 2020 Mar 27;15(3):e0230580.

9.      Wu M, Dan C, Gui JF, Zhang YB^*. Fish species-specific TRIM gene FTRCA1 negatively regulates interferon response through attenuating IRF7 transcription. Fish & Shellfish Immunology, 2019;90:180-187.

10.   Wu M, Zhao X, Gong XY, Wang Y, Gui JF, Zhang YB^*. FTRCA1, a species-specific member of finTRIM family, negatively regulates fish interferon response through autophage-lysosomal degradation of TBK1. Journal of Immunology, 2019,  202  (8):  2407-2420

11.   Gong XY, Zhang QM, Gui JF, Zhang YB^*. SVCV infection triggers fish IFN response through RLR signaling pathway. Fish & Shellfish Immunology, 2019, 86:1058-1063

12.   Zhang QM, Zhao X, Li Z, Wu M, Gui JF, Zhang YB^*. Alternative splicing transcripts of zebrafish LGP2 gene differentially contributes to interferon antiviral response. Journal of Immunology, 2018,  200  (2):  688-703

13.   Gao FX, Lu WJ, Wang Y, Zhang QY, Zhang YB, Mou CY, Li Z, Zhang XJ, Liu CW, Zhou L, Gui JF. Differential expression and functional diversification of diverse immunoglobulin domain-containing protein (DICP) family in three gynogenetic clones of gibel carp. Dev Comp Immunol. 2018;84:396-407.

14.   Kim BS, Lu H, Ichiyama K, Chen X, Zhang YB, Mistry NA, Tanaka K, Lee YH, Nurieva R, Zhang L, Yang X, Chung Y, Jin W, Chang SH, Dong C. Generation of RORγt+ Antigen-Specific T Regulatory 17 Cells from Foxp3+ Precursors in Autoimmunity. Cell Rep. 2017;21(1):195-207.

15.   熊亞瑋，張義兵^*，桂建芳。斑馬魚(yú)IRF11基因的鑒定、亞細胞定位及表達特征。水生生物學(xué)報，2017 , 41 (1) :1-8。

16.   Feng H, Zhang QM, Zhang YB^*, Li Z, Zhang J, Xiong YW, Wu M, Gui JF. Zebrafish IRF1, IRF3, and IRF7 differentially regulate IFNΦ1 and IFNΦ3 expression through assembly of homo- or heteroprotein complexes. Journal of Immunology, 2016, 197(5):1893-904.

17.   Chen C, Zhang YB^*, Gui JF. Expression characterization, genomic structure and function analysis of fish ubiquitin-specific protease 18 (USP18) genes. Dev Comp Immunol, 2015, 52:112–122。

18.   Feng H, Zhang YB^*, Zhang QM, Li Z, Zhang QY, Gui JF^*. Zebrafish IRF1 regulates IFN antiviral response through binding to IFNj1 and IFNj3 promoters downstream of MyD88 signaling. Journal of Immunology, 2015, 194: 1225–1238.

19.   Sun F, Zhang YB^*, Jiang J, Wang B, Chen C, Zhang J, Gui JF^*. Gig1, a novel antiviral effector involved in fish interferon response. Virology, 2014,448:322–332

20.   Li S, Lu LF, Feng H, Wu N, Chen DD, Zhang YB, Gui JF, Nie P, Zhang YA. IFN regulatory factor 10 is a negative regulator of the IFN responses in fish. J Immunol, 2014, 193(3):1100-9.

21.   Liu TK, Zhang YB^*, Liu Y, Sun F, Gui JF^*. Cooperative roles of fish protein kinase containing Z-DNA binding domains and double-stranded RNA-dependent protein kinase in interferon-mediated antiviral response. Journal of Virology. 2011, 85(23):12769-80.

22.   Zhang YB^*, Gui JF^*. Molecular regulation of interferon antiviral response in fish. Developmental and Comparative Immunology. 2012,38:193-202

23.   Sun F, Zhang YB^*, Liu TK, Shi J, Wang B, Gui JF^*. Fish MITA serves as a mediator for distinct fish IFN gene activation dependent on IRF3 or IRF7. Journal of Immunology. 2011, 187(5):2531-9.

24.   Sun F, Zhang YB^*, Liu TK, Gan L, Yu FF, Liu Y, Gui JF^*.Characterization of fish IRF3 as an IFN-inducible protein reveals evolving regulation of IFN response in vertebrates. Journal of Immunology. 2010,185:7573-7582.

25.   Yu FF, Zhang YB^*, Liu TK, Liu Y, Sun F, Jiang J, Gui JF^*.Fish virus-induced interferon exerts antiviral function through Stat1 pathway. Molecular Immunology. 2010, 47(14):2330-2341.

26.   Zhu R, Zhang YB, Zhang QY, Gui JF. Functional domains and the antiviral effect of the dsRNA-dependent protein kinase PKR from Paralichthys olivaceus. Journal of Virology, 2008, 82(14):6889-901.

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