職 稱(chēng): | 研究員 |
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學(xué) 歷: | 博士研究生 |
聯(lián)系方式: | 86-27-68780087 |
電子郵件: | w-xiao@ihb.ac.cn |
辦 公 室: | 2號實(shí)驗樓510 |
個(gè)人網(wǎng)頁(yè): | http://www.ihb.cas.cn/yjdw/yjy/index_83634.html?json=http://sourcedb.ihb.cas.cn/cn/gb/yjy1/ssswfzyxbswxyjzx_172773/200907/t20090722_5749614.json |
1985.9-1989.6 武漢大學(xué) 細胞生物學(xué)專(zhuān)業(yè) 本科 1989.9-1992.6 中國科學(xué)院水生生物研究所 水生生物學(xué)專(zhuān)業(yè) 碩士 1994.9-1997.8 中國科學(xué)院水生生物研究所 水生生物學(xué)專(zhuān)業(yè) 博士 |
1992.7-1994.9 中國科學(xué)院水生生物研究所 研究實(shí)習員 1994.10-1998.10 中國科學(xué)院水生生物研究所 助理研究員 1998.11-2003.10 美國西北大學(xué) 博士后/研究助理 2003.10-2005.12 美國西北大學(xué) 研究助理教授 2005.12至今 中國科學(xué)院水生生物研究所研究員 |
遺傳學(xué)(碩士生,博士生) |
1. 魚(yú)類(lèi)耐低氧的分子機制與耐低氧新品種培育的遺傳基礎 2. 魚(yú)類(lèi)抗病毒感染的分子機制與抗病新品種培育的遺傳基礎 3. 魚(yú)類(lèi)低氧脅迫反應與抗病毒先天免疫反應交互作用的分子機制 |
1. 2019.1-2023.12 國家自然科學(xué)基金重點(diǎn)項目:鯽耐低氧優(yōu)良性狀的遺傳基礎,284萬(wàn)元,主持 2. 2018.10-2022.11 國家重點(diǎn)研發(fā)計劃“藍色糧倉”項目:重要養殖生物生物應對低氧脅迫的生理和發(fā)育響應機制與生態(tài)效應研究,289萬(wàn),主持 3. 2018.1-2023.12 國家自然科學(xué)基金創(chuàng )新群體項目:魚(yú)類(lèi)分子設計育種,200萬(wàn),參加 4. 2019.10-2023.12 中國科學(xué)院先導專(zhuān)項A:鯉逆境脅迫響應的分子網(wǎng)絡(luò ),600萬(wàn),主持 |
本實(shí)驗室聚焦于魚(yú)類(lèi)耐低氧和抗病的遺傳基礎,開(kāi)展了系統的研究工作,取得了一些原創(chuàng )性的結果,發(fā)表了一系列研究論文。 代表性論文:(通訊作者用*標明) 1. Junji Zhu, Xiong Li, Xiaolian Cai, Huangyuan Zha, Ziwen Zhou, Xueyi Sun, Fangjing Rong, Jinghua Tang, Chunchun Zhu, Xing Liu, Sijia Fan, Jing Wang, Qian Liao, Gang Ouyang, Wuhan Xiao*. Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity. Molecular Cell, 2021, 81, 1-16. 2. Xiaolian Cai , Ziwen Zhou, Junji Zhu , Qian Liao , Dawei Zhang , Xing Liu , Jing Wang , Gang Ouyang , Wuhan Xiao* . Zebrafish hif-3α modulates erythropoiesis via regulation of gata-1 to facilitate hypoxia tolerance. Development, 2020, doi: 10.1242/dev.185116. 3. Guangqing Yu , Xing Liu , Dawei Zhang, Jing Wang, Gang Ouyang , Zhu Chen, Wuhan Xiao *. Zebrafish nedd8 facilitates ovarian development and the maintenance of female secondary sexual characteristics via suppression of androgen receptor activity. Development, 2020, 147(18): dev.194886. 4. Xing Liu , Chunchun Zhu, Huangyuan Zha , Jinhua Tang , Fangjing Rong, Xiaoyun Chen , Sijia Fan , Chenxi Xu , Juan Du, Junji Zhu, Jing Wang , Gang Ouyang , Guangqing Yu , Xiaolian Cai , Zhu Chen , Wuhan Xiao *. SIRT5 impairs aggregation and activation of the signaling adaptor MAVS through catalyzing lysine desuccinylation. EMBO Journal, 2020, 39(11): e103285. 5. Junji Zhu, Dawei Zhang, Xing Liu, Guangqing Yu, Xiaolian Cai, Chenxi Xu, Fangjing Rong, Gang Ouyang, Jing Wang, Wuhan Xiao*. Zebrafish prmt5 arginine methyltransferase is essential for germ cell development. Development, 2019, 146(20): dev179572. 6. Chenxi Xu, Xing Liu, Huangyuan Zha, Sijia Fan, Dawei Zhang, Wuhan Xiao*. A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1α protein. PLoS Pathogens, 2018, 18(8): e1007259. 7. Jing Wang, Dawei Zhang, Juan Du, Chi Zhou, Zhi Li, Xing Liu, Gang Ouyang, Wuhan Xiao*. Tet1 facilitates hypoxia tolerance by stabilizing the HIF-α proteins independent of its methylcytosine dioxygenase activity. Nucleic Acids Research, 2017,45(22): 12700-12714. 8. Yu Chen, Chi Zhou, Wei Ji, Zhichao Mei, Bo Hu, Wei Zhang, Dawei Zhang, Jing Wang, Xing Liu, Gang Ouyang, Jiangang Zhou, Wuhan Xiao*. ELL targets c-Myc for proteasomal degradation and suppresses tumor growth. Nature Communications, 2016, 7: 11057. 9. Xing Liu, Zhu Chen, Chenxi Xu, Xiaoqian Leng, Hong Cao, Gang Ouyang, Wuhan Xiao*. Repression of hypoxia-inducible factor alpha signaling by Set7-mediated methylation. Nucleic Acids Research, 2015, 43(10): 5081-5098. 10. Xi Feng, Xing Liu, Wei Zhang, Wuhan Xiao*. p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death. EMBO Journal, 2011, 30: 3397-3415. |