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            中國科學(xué)院水生生物研究所歡迎您的來(lái)訪(fǎng)！
        
        
        
    
        

        

        
    
        
        
        
            
        
                
            
        
            
        
                
        
                    
                
        
            
        
        
        
    
        

        





        
    
        
        
        
            

        
        
        
        
            
        
                
                
                
        
					  
        
						  
        侯宏偉　研究員
        博士研究生
        
						  
        
							
        
								
        
							
        
							
        
								
        
                                    
        
                                            
                                              
        
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                                                研究員
                                              
        
                                              
        
                                                學(xué)　　歷：
                                                博士研究生
                                              
        
                                              
        
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        教育經(jīng)歷
                    
                                
        1985.9-1989.6 河南師范大學(xué) 生物專(zhuān)業(yè) 本科
                    
        1999.9-2004.7 北京大學(xué)生命科學(xué)學(xué)院 植物學(xué)專(zhuān)業(yè) 碩博連讀
                            		        
            
        主要職歷
                    
                                
        2004.8-2008.3 University of Lethbridge 博士后
                    
        2008.4-2010.7 多倫多大學(xué) 博士后
                    
        2010.8-2014.2加拿大農業(yè)部London發(fā)展研究中心和Lethbridge發(fā)展研究中心
                    
        2014.3-至今 中國科學(xué)院水生生物研究所 研究員/博士生導師
                            		        
            
        招生專(zhuān)業(yè)
                    
                                
        遺傳學(xué)（碩士生，博士生）
                            		        
            
        研究方向
                    
                                
        1. 環(huán)境因子對植物表型的調控和機制研究
                    
        “異形葉”指基因型相同的植物由于環(huán)境差異，葉形出現顯著(zhù)差異的現象，這種現象為研究環(huán)境對表型的調控作用提供了一個(gè)理想研究模型。通過(guò)篩選，我們發(fā)現一種水族觀(guān)賞植物 – 爵床科（Acanthaceae）的異葉水蓑衣（Hygrophila difformis）的葉形在陸生和水生條件下差異顯著(zhù)，該植物易于擴繁和遺傳轉化，以此植物為主要研究材料，研究環(huán)境、基因和植物激素等對異形葉形態(tài)的調控關(guān)系，闡明環(huán)境因子調控異形葉形態(tài)的基因調控網(wǎng)絡(luò )和主要途徑。
                    
        2. 浮萍研究及應用
                    
        浮萍（Duckweed）屬天南星科（Araceae）浮萍亞科(Lemnoideae)的水生高等植物，廣布于各種淡水生境，包括紫萍(Spirodela)、斑萍(Landoltia)、青萍(Lemna)、扁無(wú)根萍 (Wolffiella)、蕪萍(Wolffia)5屬，36種。浮萍具有個(gè)體小、結構簡(jiǎn)單、繁殖快等特點(diǎn)，適宜于工廠(chǎng)化生產(chǎn)，使其在研究植物形態(tài)建成、發(fā)育和進(jìn)化，以及生物技術(shù)應用等方面有極大潛力。我們從種質(zhì)、培養和遺傳轉化入手，結合形態(tài)解剖、基因組學(xué)等方法研究浮萍器官退化的機制；研究了浮萍的營(yíng)養類(lèi)型、低硫、低磷脅迫的信號途徑；篩選了適于監測和富集重金屬的浮萍品系，并對Nramps（金屬離子轉運蛋白）、PCS（植物絡(luò )合素）、GSH（谷胱甘肽）等重金屬轉運相關(guān)蛋白編碼基因進(jìn)行了克隆和功能研究。
                    
        3. 水生植物生態(tài)學(xué)研究
                    
        水生植物是湖泊、濕地等淡水生態(tài)系統重要的初級生產(chǎn)者，是水生生物群落多樣性的基礎，也是維持生態(tài)系統運轉的關(guān)鍵類(lèi)群，其多樣性、環(huán)境適應和種群動(dòng)態(tài)同樣具有重要意義。以高原和長(cháng)江流域的重要湖泊為對象，采用綜合營(yíng)養狀態(tài)指數法對湖泊的營(yíng)養水平現狀進(jìn)行評估；我們選擇代表性的水生植物，如：菱（Trapa bispinosa）、苦草（Vallisneria natans）、金魚(yú)藻（Ceratophyllum demersum）等，用分子標記、甲基敏感多態(tài)性分析（MSAP）和微衛星標記（Microsatellite）等方法揭示不同的時(shí)空因素對物種、種群和個(gè)體水平的多樣性和遺傳格局的影響，揭示水生植物的分布、遺傳多樣性演變的規律及其在淡水生態(tài)系統中的功能。 
                    
        4. 水生蔬菜研究
                    
        通過(guò)多種栽培方式和組織培養等方法，研究水芹(Oenanthe javanica)、豆瓣菜（Nasturtium officinale）等水生蔬菜在水、溫度等逆境脅迫下的生理變化和基因表達，鑒定重要性狀基因，篩選優(yōu)良種質(zhì)。
                            		        
            
        承擔項目情況
                    
                                
        1. 2020.9-2023.8 中科院國際合作重點(diǎn)項目(中日合作)-水生植物異形葉的發(fā)育、生態(tài)和進(jìn)化研究，109.9萬(wàn)元，主持；
                    
        2. 2019.8-2022.7 國家重點(diǎn)研發(fā)計劃項目（政府間科技創(chuàng  )新合作重點(diǎn)專(zhuān)項，中日合作，2017YFE0128800）-水生植物異形葉研究模型及形態(tài)的調控研究，266萬(wàn)元，主持；
                    
        3. 2019.1-2021.12 國家重點(diǎn)研發(fā)計劃“藍色糧倉科技創(chuàng  )新”重點(diǎn)專(zhuān)項（2018YFD0900800）-漁業(yè)水域生境退化與生物多樣性演變機制，83萬(wàn)元，參與； 
                    
        4. 2019.1-2021.12 國家自然科學(xué)基金面上項目（31870384）-環(huán)境因子調控異葉水蓑衣異形葉形態(tài)建成的機制研究，70.8萬(wàn)元，主持； 
                    
        5. 2017.11-2020.12 湖北省技術(shù)創(chuàng  )新專(zhuān)項重大項目（2017ABA135）-利用菌、藻綜合處理畜禽養殖廢水關(guān)鍵技術(shù)研發(fā)，100萬(wàn)元，主持;
                    
        6. 2015.9-2016.12 留學(xué)人員科技活動(dòng)項目-大型水生植物的基因改良及其在汞污染監測和修復中的應用研究，10萬(wàn)，主持；
                    
        7. 2015.1-2017.12 湖北省自然科學(xué)基金面上項目（2015CFB488）-大型水生植物的基因改良及其在汞污染治理中的應用，3萬(wàn)，主持；
                            		        
            
        科研成果
                    
                                
        先后主持“國家重點(diǎn)研發(fā)計劃項目”、“國家自然科學(xué)基金面上項目”、“中國科學(xué)院國際合作重點(diǎn)專(zhuān)項項目”、“湖北省科技創(chuàng  )新重大項目”、“中國科學(xué)院-湖北省院地合作”項目、人社部“留學(xué)人員科技活動(dòng)”項目、“湖北省自然科學(xué)基金”等項目15項。在植物生理學(xué)、生態(tài)學(xué)和植物遺傳學(xué)等研究領(lǐng)域的國內外學(xué)術(shù)期刊上發(fā)表論文40余篇，包括“科學(xué)通報”、“植物生理學(xué)報”、“水生生物學(xué)報”、“Plant Cell”、“Plant Journal”、“Planta”、“Journal of Experimental Botany”、“Bioresource Technology”、“Antioxidants”、”Frontiers in Immunology”、“Plant Cell Reports”、“BMC Evolutionary Biology”、“Frontiers in Plant Sciences”等學(xué)術(shù)期刊。
                    
         
                    
        代表性論文：
                    
         
                    
        1.    X. Zhao, J. Yang, G. Li, Z. Sun, S. Hu, Y Chen, W. Guo, H. Hou*. Genome-wide identification and comparative analysis of the WRKY gene family in aquatic plants and their response to abiotic stresses in giant duckweed (Spirodela polyrhiza), Genomics, 2021, 113(4). 
                    
        2.    G. Li, S. Hu, X. Zhao, S. Kumar, Y. Li, J. Yang*, H. Hou*, Mechanisms of the morphological plasticity induced by phytohormones and the environment in plants, International Journal of Molecular Sciences, 2021, 22 (2): 765. 
                    
        3.    S. Kumar, G. Li, X. Huang, Q Ji, K Zhou, H. Hou, W. Ke*, J. Yang*. Phenotypic, nutritional, and antioxidant characterization of blanched Oenanthe javanica for preferable cultivar, Frontiers in Plant Science, 2021. 
                    
        4.    S. Kumar, G. Li, J. Yang, X. Huang, Q Ji, K Zhou, S. Khan, W. Ke *, H. Hou*. Investigation of an antioxidative system for salinity tolerance in Oenanthe javanica, Antioxidants, 2020, 9, 940. 
                    
        5.    Z. Sun, W. Guo, J. Yang, X. Zhao, Y Chen, L. Yao, H. Hou*. Enhanced biomass production and pollutant removal by duckweed in mixotrophic conditions, Bioresource Technology, 2020, 317, 124029.
                    
        6.    G. Li, S. Hu, J. Yang, X. Zhao, E. Schultz, S. Kimura, H. Hou*. Establishment of an Agrobacterium mediated transformation protocol for the detection of cytokinin in the heterophyllous plant Hygrophila difformis (Acanthaceae), Plant Cell Reports, 2020, 39(3). 
                    
        7.    Z. Wu, X Xu, J Zhang, G. Wiegleb, H. Hou*. Influence of environmental factors on the genetic variation of the aquatic macrophyte Ranunculus subrigidus on the Qinghai-Tibetan Plateau, BMC Evolutionary Biology, 2019, 19: 228. 
                    
        8.    G. Li, S. Hu, H. Hou, S. Kimura*. Heterophylly: phenotypic plasticity of leaf shape in aquatic and amphibious, Plants, 2019, 8(10), 420. 
                    
        9.    S. Khan, Y Liu, R. Siddique, G. Nabi, M. Xue *, H. Hou*. Impact of chronically alternating light-dark cycles on circadian clock mediated expression of cancer (glioma)-related genes in the brain, International Journal of Biological Sciences 2019, 15(9): 1816-1834. 
                    
        10. S. Khan, M. W. Ullah, R. Siddique, Y Liu, I. Ullah, M. Xue*, G Yang*, H. Hou*. Catechins-modified selenium-doped hydroxyapatite nanomaterials for improved osteosarcoma therapy through generation of reactive oxygen species, Frontiers in Oncology, 2019, 9: 499. 
                    
        11. J. Yang, G. Li, S. Hu, A. Bishopp, P. P. M. Heenatigala, S. Kumar, P. Duan, L. Yao, H. Hou*. A protocol for efficient callus induction and stable transformation of Spirodela polyrhiza (L.) Schleiden using Agrobacterium tumefaciens, Aquatic Botany, 2018, 151: 80-86. 
                    
        12. P. P. M. Heenatigala, J. Yang, A. Bishopp, Z. Sun, G. Li, S. Kumar, S. Hu, Z. Wu, W Lin, L. Yao, P. Duan, H. Hou*. Development of efficient protocols for stable and transient gene transformation for Wolffia globosa using Agrobacterium, Frontiers in Chemistry, 2018, 6: 227. 
                    
        13. J. Yang, G. Li, A. Bishopp, P. P. M. Heenatigala, S. Hu, Y Chen, H. Hou*. A comparison of growth on mercuric chloride for three Lemnaceae species reveals differences in growth dynamics that effect their suitability for use in either monitoring or remediating ecosystems contaminated with mercury, Frontiers in Chemistry, 2018, 6: 112. 
                    
        14. N. Mariyamma, K. Clarke, H Yu, H. Hou, E. Wilton, J. Dyk, E. Schultz*. Members of the Arabidopsis FORKED1-LIKE gene family act to localize PIN1 in developing veins. Journal of Experimental Botany, 2018, 69 (20): 4773–4790. 
                    
        15. S. Khan, G. Nabi, L Yao*, R. Siddique, W. Sajjad, S. Kumar, P. Duan, H. Hou*. Health risks associated with genetic alterations in internal clock system by external factors. International Journal of Biological Sciences, 2018, 14 (7): 791–798. 
                    
        16. S. Khan, P. Duan, L Yao*, H. Hou*. Shiftwork-mediated disruptions of circadian rhythms and sleep homeostasis cause serious health problems. International Journal of Genomics, 2018, 2018: 8576890.
                    
        17. G. Li, S. Hu, J. Yang, E. Schultz, K. Clarke, H. Hou*. Water-Wisteria as an ideal plant for heterophylly study in higher aquatic plants, Plant Cell Reports, 2017, 36 (8):1225–1236. 
                    
        18. S. Hu, G. Li, J. Yang, H. Hou*. Aquatic plant genomics: advances, applications, and prospects, International Journal of Genomics, 2017: 6347874. 
                    
        19. Z. Wu, J Wu, Y Wang, H. Hou *. Development of EST-derived microsatellite markers in the aquatic macrophyte Ranunculus bungei (Ranunculaceae), Applications in Plant Sciences, 2017, 5: 1700022. 
                    
        20. N. Mariyamma, H. Hou, F. Carland, T. Nelson, E. Schultz*. Localization of Arabidopsis FORKED1 to a RABA positive compartment suggests a role in secretion, Journal of Experimental Botany, 2017, 68 (13): 3375–3390. 
                    
        21. S. Khan, R. Siddique, G. Nabi, Q Li, H..Hou*, I. Ali*. Investigation of sewage and drinking water in major healthcare centres for bacterial and viral pathogens, Hydrology: Current Research, 2017, 8: 2.1000272. 
                    
        22. S. Khan, M. Ullah, R. Siddique, G. Nabi, S. Manan, M. Yousaf, H. Hou*. Role of recombinant DNA technology to improve life, International Journal of Genomics, 2016: 2405954. 
                    
        23. S. Shen, H. Hou, C. Ding, D. Bing, Z. Lu*. Protein content correlates with starch morphology, composition and physicochemical properties in field peas. Canadian Journal of Plant Sciences, 2016, 96 (3): 404–412. 
                    
        24. S. Khan, G. Nabi, M. W. Ullah, M. Yousaf, S. Manan, R. Siddique, H. Hou*. Overview on the role of advance genomics in conservation biology of endangered species, International Journal of Genomics, 2016: 3460416. 
                    
        25. H. Hou *, N. Atlihan, Z. Lu*. New biotechnology enhances the application of cisgenesis in plant breeding, Frontiers in Plant Science, 2014, 5: 389.
                    
        26. M. Held#, H. Hou#, M. Miri#, C. Huynh, L. Ross, M. S. Hossain, S. Sato, S. Tabata, J. Perry, T. Wang, K. Szczyglowski*. Lotus japonicas cytokinin receptors work partially redundantly to mediate nodule formation, The Plant Cell, 2014, 2, 282 : 678-6946. 
                    
        27. H. Yoon #, M. Hossain #, M. Held, H. Hou, M. Kehl, A. Tromas, S. Sato, T. Tabata, S. Andersen, J. Stougaard, L. Ross, K. Szczyglowski*. Lotus japonicus SUNERGOS1 encodes apredicted subunit A of a DNA topoisomerase VI and is required for nodule differentiationand accommodation of rhizobial infection, The Plant Journal, 2014, 3, 24, 78 (5): 811-821. 
                    
        28. H. Hou, Z. Zhang*, W. Zhao, J. Hou, Generating DNA sequences encoding tandem peptide repeats suitable for expression and immunological application, World J Microbiol Biotechnol, 2012, 2, 22, 28: 2175-2180. 
                    
        29. J. Garrett#, M. Meents, M. Blackshaw, L. Blackshaw, H. Hou, D. Styranko, S. Kohalmi, E. Schultz*. A novel, semi-dominant allele of MONOPTEROS provides insight into leaf initiation and vein pattern formation, Planta, 2012, 2, 21, 236(1). 
                    
        30. H. Hou, J. Erickson, J. Meservy, E. Schultz*. FORKED1 encodes a PH domain proteinthat is required for PIN1 canalization in developing leaf veins, The Plant Journal, 2010, 8, 3, 63: 960-973.
                    
        31. H. Hou#, Y Zhou#, K. Mwange#, W Li, X He, K Cui *. ABP1 expression regulated by IAA and ABA is associated with the cambium periodicity in Eucommia ulmoides Oliv, Journal of Experimental Botany, 2006, 10, 9, 57 (14): 3857-3867.
                    
        32. K. Mwange #, H. Hou #, Y Wang, X He, K Cui *. Opposite patterns in the annual distribution and time course of endogenous abscisic acid and indole-3-acetic acid in relation to the periodicity of cambial activity in E. ulmoides, Journal of Experimental Botany, 2005, 2, 14, 56 (413): 1017-1028. 
                    
        33. K. Mwange, H. Hou, K. Cui*. Relationship between endogenous indole-3-acetic acid and abscisic acid changes and bark recovery in E. ulmoides after girdling, Journal of Experimental Botany, 54 (389), pp 1899-1907, 2003/5/2. 
                    
        34. H. Hou, K. N. Mwange, K. Cui. Changes of Soluble Protein, Peroxidase Activity and Distribution during Regeneration after Girdling in Eucommia ulmoides, Acta Botanica Sinica, 2004, 46 (2): 216-223.
                    
        35. K. Mwange#, H. Hou#, Y Wang, X He, K Cui*. Opposite patterns in the annual distribution and time course of endogenous abscisic acid and indole-3-acetic acid in relation to the periodicity of cambial activity in Eucommia ulmoides, Journal of Experimental Botany, 2005, 56: 1017–1028.
                    
        36. H. Hou, Seasonal variation of auxin binding protein 1 (ABP1) in the cambial region and ultrastructural and peroxidase analysis during bark regeneration in Eucommia ulmoides, 2004, Ph. D Dissertation of Peking University, China
                    
        37. 楊晶晶, 趙旭耀, 李高潔, 胡詩(shī)琦, 陳艷, 孫作亮，侯宏偉*. 浮萍的研究及應用進(jìn)展, 科學(xué)通報, 2021, doi: 10.1360/TB-2020-0927.
                    
        38. 李高潔，胡詩(shī)琦，楊晶晶，侯宏偉*. 植物異形葉研究進(jìn)展, 植物生理學(xué)報，2020, 56 (10): 2067-2078.
                    
        39. 吳志剛, 熊文, 侯宏偉*. 長(cháng)江流域水生植物多樣性格局與保護. 水生生物學(xué)報 2018. 43: 1000-3207.
                    
        專(zhuān)利：
                    
        1． 一種農桿菌介導的紫萍穩定轉化體系建立的方法，申請號：201610518360.x
                    
        論著(zhù)：
                    
        1.    J. Yang, S. Hu, G. Li, H. Hou. The Duckweed Genomes: Transformation Development in Duckweeds, New York: Springer nature, (Eds): 2019, 978-3-030-11044-4, 455980_1_En, (15).
                            		        
            
        社會(huì )任職
                    
                                
        “植物生理學(xué)學(xué)報”期刊編委
                            		        
            
        培養研究生情況
                    
                                
        畢業(yè)研究生：
                    
        楊晶晶，2018年博士畢業(yè)，在中科院水生所任職
                    
        Prajani Heenatigala, 2018年博士畢業(yè)，在斯里蘭卡國家水資源研發(fā)局（NARA）任職
                    
        李高潔，2019年博士畢業(yè)，在中科院水生所任職
                    
        Suliman Khan, 2019年博士畢業(yè)，在鄭州大學(xué)任職
                    
        孫作亮，2020年碩士畢業(yè)，在中科院水生所攻讀博士學(xué)位
                    
        胡詩(shī)琦，2020年博士畢業(yè)，在浙江省海洋開(kāi)發(fā)研究院任職