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簡(jiǎn)歷介紹：

博士，研究員，博士生導師。2004年于武漢大學(xué)生命科學(xué)院獲博士學(xué)位；2004-2007年華中農業(yè)大學(xué)水產(chǎn)學(xué)院講師；2007-2015年先后在德國馬普發(fā)育生物學(xué)所和美國佐治亞大學(xué)生化與分子生物學(xué)系做博士后研究。2015年受聘為中科院水生生物研究所研究員。長(cháng)期從事脊椎動(dòng)物早期胚胎發(fā)育機制以及多能干細胞自我更新及分化的研究,系統研究了轉錄因子、信號通路、表觀(guān)遺傳因子以及染色質(zhì)高級結構在多能干細胞自我更新和分化、譜系命運決定中的作用機制。在《CELL》《Cell Stem Cell》《Developmental Cell》《G&D》《Stem Cell Reports》《Stem Cells》等國際著(zhù)名刊物上發(fā)表SCI文章15篇以上，論文累計被引超過(guò)1000次。擔任Frontiers in Cell and Developmental Biology的編委。

研究方向：

1.以斑馬魚(yú)為模式生物，研究脊椎動(dòng)物早期胚胎發(fā)育的分子機制 

2.胚胎干細胞自我更新和分化機制研究 

3.基于多能干細胞的類(lèi)器官構建，干細胞治療和轉化醫學(xué)研究 

代表論著(zhù)：

1.Sun, X., Peng, X., Cao, Y., Zhou, Y., and Sun, Y. (2020a). ADNP promotes neural differentiation by modulating Wnt/beta-catenin signaling. Nature Communications 11, 2984, doi:10.1038/s41467-020-16799-0 (2020). 

2.Sun, X., Yu, W., Li, L., and Sun, Y. (2020b). ADNP Controls Gene Expression Through Local Chromatin Architecture by Association With BRG1 and CHD4. Frontiers in cell and developmental biology 8, 553, doi:10.3389/fcell.2020.00553 (2020) 

3.Sun, X.Y., Chen, J., Zhang, Y.Y., Munisha, M., Dougan, S., and Sun, Y.H. (2018). Mga Modulates Bmpr1a Activity by Antagonizing Bs69 in Zebrafish. Frontiers in cell and developmental biology 6, doi:Unsp 12610.3389/Fcell.2018.00126 (2018). 

4.Ryan Berger, Yuhua Sun et al., (2016). ST8SIA4-dependent polysialylation is part of a developmental program required for germ layer formation from human pluripotent stem cells. Stem Cells, DOI: 10.1002/stem.2379 　　  

5.Amar Singh*, Yuhua Sun*, Li Li, Steve Qin, and Steve Dalton (2015). Cell-Cycle  Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency. Stem Cell Reports，3:323 (*equal contribution) 　　  

6.Yuhua Sun, Weichia Tseng, Rebecca Ball,and Scott Dougan (2014). Extra-embryonic signals under the control of Mga, Max and Smad4 are required for dorsoventral patterning. Developmental Cell, 28: 322 　　  

7.J Champell*, YH Sun*, A Singh, S Dalton (2013). Myc/Max control Erk signaling and pluripotency by regulation of dual specificity phosphatases 2 and 7. Genes & Development (*equal contribution), 27:725-733 　　  

8.J Phillips-Cremins, M Sauria, A Sanyal, T Gerasimova, B Lajoie, J Bell, CT Ong, T Hookway, C Guo, YH Sun, M Bland, W Wagstaff, S Dalton, T McDevitt, R Sen, J Dekker, J Taylor, V Corces (2013)．Architectural protein subclasses shape 3- D organization of genomes during lineage commitment．Cell, 153: 1281 　　  

9.Amar M. Singh, David Reynoids, Timothy Cliff, Satoshi Ohtsuka, Alexa Mattheyses, Yuhua Sun, Laura Menendez, Michael Kulik and Stephen Dalton (2012). Signaling Network Crosstalk in Human Pluripotent Cells: A Smad2/3-Regulated Switch that Controls the Balance between Self-Renewal and Differentiation. Cell stem cell, 10(3): 312-326   

10.Sun YH, Wloga D. and Dougan S. (2011). Embryological manipulations in zebrafish. Methods Mol. Biol., 770: 139-184 　　  

11.D.M. Webster, C.F. Teo, YH. Sun, D. Wloga, S. Gay, L. Wells and S. T. Dougan (2009). O-GlcNAc modifications regulate cell survival and epiboly during zebrafish development. BMC Dev. Biol., 9(1): 28-33 Highly Accessed Article 　　  

12.Chengtai Yang, Ling Cao, Weimin Wang, Yi Yang, Binlun Yan, Li Su, Yuhua Sun, and Huanling Wang (2009). Comparative and evolutionary analysis in natural diploid and tetraploid weather loach Misgurnus anguillicaudatus based on cytochrome b sequence data in central China. Environmental Biology of Fishes, 86(1): 145-153 　  

13.Treer T., Sprem N, Torcu-Koc, YH Sun, and M. Piria (2008). Length-weight relationship of freshwater fishes of Croatia. J. Appl. Ichthyol, 24: 626-628   

14.Yuhua Sun, Rong Tang, Dapeng Li, Xuezhen Zhang, Juan Fu, Ping Xie (2008). Acute effects of microcystins on transcription of antioxidant enzyme genes in crucian carp. Environ. Toxicol., 23: 145-152  　  

15.Zexia Gao, *Weimin Wang, Khalid Abbas, Xiaoyun Zhou, Yi Yang, James S Diana, Hanping Wang, Huanling Wang, Yang Li, Yuhua Sun (2007). Haematological characterization of loach Misgurnus anguillicaudatus: comparison among diploid, triploid and tetraploid specimens. Comp Biochem Physiol A Mol Integr Physiol. 2007 Aug;147-   

16.YH Sun, CX Xie, WM Wang, SY Liu, T. Treer, MM Chang et al (2007). The genetic variation and the biogeography of catostomid fishes based on mitochondrial and nucleic DNA sequences. Journal of Fish Biology, 70: 291-309  　　  

17.Yuhua Sun, Siyang Liu, Gang Zhao, QX Yu et al (2004). Population structure of Chinese sucker Myxocyprinus asiatus (Cypriniformes: Catostomidae) in the Yangtze River based on Mitochondrial DNA control region sequences. Fisheries Science, 70(3): 412-420 　　  

18.SUN Yu-Hua; WANG Wei; LIU Si-Yang; HE Shun-Ping; SHAO Xue-Ling; XIE Zhi-Xiong; DENG Feng-Jiao; LIU Yong; TONG Jin-Gou; WU Qing-Jiang (2002). Genetic Diversity Analysis of Mitochondrial D-loop Region of Chinese Sucker (Myxocyprinus asiaticus). Journal of Genetics and Genomics (in Chinese), 29(9): 787-790