職 稱(chēng): | 研究員 |
---|---|
學(xué) 歷: | 博士研究生 |
聯(lián)系方式: | 86-27-68780989 |
電子郵件: | cczhang#ihb.ac.cn(請改#為@) |
辦 公 室: | 3號樓202 |
個(gè)人網(wǎng)頁(yè): |
1980.9-1984.6 山東師范大學(xué) 生物學(xué)專(zhuān)業(yè) 本科 1985.8-1986.7 法國??怂?span lang="EN-US">-馬賽大學(xué) 細胞生物學(xué)和微生物學(xué)專(zhuān)業(yè) 碩士 1986.8-1989.6 法國??怂?span lang="EN-US">-馬賽大學(xué) 細胞生物學(xué)和微生物學(xué)專(zhuān)業(yè) 博士 |
1989.7-1991.7 瑞士蘇黎士大學(xué) 博士后 1991.7-1999.6 法國斯路易巴斯德大學(xué) 講師 1999.8-2015.5 法國??怂?span lang="EN-US">-馬賽大學(xué) 教授 2015.6-至今 中國科學(xué)院水生生物研究所 研究員 2017.1-至今 中國科學(xué)院藻類(lèi)生物學(xué)重點(diǎn)實(shí)驗室 主任 |
遺傳學(xué)(碩士生,博士生) |
原核生物細胞發(fā)育、信號傳導等基礎生物學(xué)研究 以藍細菌為材料,利用分子遺傳學(xué)、細胞生物學(xué)、生物化學(xué)、等手段研究細胞生長(cháng)發(fā)育,及信號轉導等的分子調控機制。利用合成生物學(xué)等手段探索藍藻水華的形成機制及可能的解決方案,及藍藻毒素代謝途徑。 |
2016.8-2020.12 中國科學(xué)院項目 基于單細胞技術(shù)研究細胞發(fā)育和細胞周期的協(xié)調機制,300萬(wàn)元,主持 2019.7-2024.6 國家重點(diǎn)研發(fā)計劃合成生物學(xué)重點(diǎn)專(zhuān)項 水華藍藻合成微生物控制系統構建與應用,2883萬(wàn)元,主持 2021.1-2023.12 國家自然科學(xué)基金重大研究計劃 水圈固碳固氮主要生產(chǎn)者藍藻碳氮元素循環(huán)的耦合調控,89萬(wàn)元,主持 |
主要用藍藻作為模式,以分子遺傳學(xué)和細胞生物學(xué)為手段研究細胞生長(cháng)發(fā)育的機制,包括細胞發(fā)育和細胞周期的關(guān)系,及對環(huán)境變化適應能力分子機制。在國際期刊上發(fā)表文章97篇,其中包括PNAS, Mol Microbiol, Nucl Acid Res, J Bacteriol, FEMS Microbiol Rev,Trends in Plant Sci. 等雜志。
代表性論文: 1. Wei-Yue Xing, Jing Liu, Zi-Qian Wang, Ju-Yuan Zhang, Xiaoli Zeng, Yiling Yang and Cheng-Cai Zhang*. HetF protein is a new divisome component in a filamentous and developmental cyanobacterium. mBio, 2021, accepted. 2. Zi-Qian Wang, Suqin Wang, Ju-Yuan Zhang, Gui-Ming Lin, Nanqin Gan, Lirong Song, Xiaoli Zeng* & Cheng-Cai Zhang*. The proposed neurotoxin β-n-methylamino-l-alanine (bmaa) is taken up through amino-acid transport systems in the cyanobacterium anabaena pcc 7120. Toxins, 2020, 12(8), 518. 3. Xing, W. Y., Xie, L. R., Zeng, X., Yang, Y. *, & Zhang, C. C.*. Functional dissection of genes encoding dna polymerases based on conditional mutants in the heterocyst-forming cyanobacterium anabaena pcc 7120. Frontiers in Microbiology, 2020, 11, 1108. 4. Li Wang, Tian-Cai Niu, Gui-Ming Lin, Shao-Ran Zhang, Ju-Yuan Zhang, Guo-Fang Tang, Wenli Chen*, Cheng-Cai Zhang*. patD, a gene regulated by NtcA, is involved in the optimization of heterocyst frequency in the cyanobacterium Anabaena PCC 7120. Journal of bacteriology. 2019, 201(21). pii: e00457-19. 5. Wei-Yue Xing, Cheng-Cai Zhang*. Preventing accidental heterocyst development in cyanobacteria. Journal of bacteriology. 2019, 201 (17) e00349-19. 6. Tian-Cai Niu, Gui-Ming Lin, Li-Rui Xie, Zi-Qian Wang, Wei-Yue Xing, Ju-Yuan Zhang*, Cheng-Cai Zhang*, Expanding the potential of CRISPR-Cpf1 based genome editing technology in the cyanobacterium Anabaena PCC 7120. ACS Synth. Biol. 2019, 8:170-180. 7. Cheng-Cai Zhang*, Cong-Zhao Zhou, Robert L. Burnap, Ling Peng, Carbon/Nitrogen Metabolic Balance: Lessons from Cyanobacteria. Trends in Plant Sci. 2018, 23:1116-1130. 8. Yali Wang, Yuan Gao, Chao Li, Hong Gao, Cheng-Cai Zhang and Xudong Xu*, Three substrains of the cyanobacterium Anabaena sp. PCC 7120 display divergence in genomic sequences and hetC function, Journal of bacteriology. 2018, 200 (13):e00076-18. 9. Ju-Yuan Zhang, Gui-Min Lin, Wei-Yue Xin and Cheng-Cai Zhang*, Diversity of the growth patterns probed in live cyanobacterial cells using a fluorescent analog of a peptidoglycan precursor. Frontiers in Microbiology,2018, 9:791. 10. Yong-Liang Jiang, Xue-Ping Wang, Hui Sun, Shu-Jing Han, Wei-Fang Li, Ning Cui, Gui-Ming Lin, Ju-Yuan Zhang, Wang Cheng, Dong-Dong Cao, Zhi-Yong Zhang, Cheng-Cai Zhang*, Yuxing Chen*, Cong-Zhao Zhou*, Coordinating carbon and nitrogen metabolic signaling through the cyanobacterial global repressor NdhR. Proc Natl Acad Sci USA. 2018, 115:403-408. 11. Hu, H-X., Jiang, Y-L., Zhao, M-X., Cai K., Liu, S., Wen, B., Lv, P., Zhang, Y., Peng, J., Yu, H.-M., Ren, Y.-M., Zhang, Z., Wu, Q., Oliveberg, M., Zhang, C.-C*., Chen, Y*., Zhou, C.Z.* Structural insights into HetR PatS interaction involved in cyanobacterial pattern formation. Scientific Reports. 2015, 5:16470. 12. Zhang, J-Y; Deng, X-M; Li, F-P; Wang, L; Huang, Q-Y; Zhang, C-C.*; Chen, W-L. RNase E forms a complex with polynucleotide phosphorylase in cyanobacteria via a cyanobacterial-specific nonapeptide in the noncatalytic region. RNA. 2014, 20:568-579. 13. Zhang S-R, Lin G-M, Chen W-L, Wang L, Zhang C-C.*. ppGpp metabolism is involved in heterocyst development in the cyanobacterium Anabaena sp. PCC 7120. Journal of bacteriology. 2013, 195:4536-4544. 14. Zhang C-C & Zhou C-Z. ATPase as a switch in PII signal transduction. Proc Natl Acad Sci USA. 2013, 110:12863-12864. 15. Boileau, C., Eme, L., Brochier-Armanet, C., Janicki, A., Zhang, C.-C.* and Latifi A. A eukaryotic-like sulfiredoxin involved in oxidative stress responses and in the reduction of the sulfinic form of 2-Cys peroxiredoxin in the cyanobacterium Anabaena PCC 7120. New Phytologist. 2011, 91:1108–1118. 16. Liu, X., Chen, H., Laurini, E., Wang, Y., Dal Col, V., Posocco, P., Ziarelli, F., Fermeglia, M., Zhang, C.-C.*, Pricl, S., and Peng, L. 2-Difluoromethylene-4-methylenepentanoic Acid, A Paradoxical Probe Able To Mimic the Signaling Role of 2-Oxoglutaric Acid in Cyanobacteria. Org. Lett. 2011, 13:2924-2927. 17. Bastet, L., Boileau, C., Janicki, A., Bedu, S., Latifi, A. and Zhang, C.-C.*. NtcA regulates patA expression in Anabaena sp. strain PCC 7120. Journal of bacteriology. 2010, 192:5257-5259. 18. Janssen, P.J., Morin, N., Mergeay, M., Leroy, B., Wattiez, R., Vallaeys, T., Waleron, R., Waleron, M., Wilmotte, A., Quillardet, P., Tandeau de Marsac, N., Talla, E., Zhang, C.-C.* and Leys, N. Genome Sequence of the Edible Cyanobacterium Arthrospira sp. PCC 8005. Journal of bacteriology. 2010, 192:2465-2466. 19. Zhao, M.-X., Jiang, Y.-L., He, Y.-X., Chen, Y.-F., Teng, Y.-B., Chen, Y., Zhang, C.-C.*, and Zhou, C.-Z.*. Structural basis for the allosteric control of the global nitrogen-regulating transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate. *Co-corresponding authors. Proc. Natl. Aacd. Sci. USA. 2010, 107:12487-12492. 20. Jang, J., Shi, L., Tan, H., Janicki, A., and Zhang, C.-C*. Mutual regulation of ntcA and hetR during heterocyst differentiation requires two similar PP2C-type protein phosphatases PrpJ1 and PrpJ2 in Anabaena sp. strain PCC 7120. Journal of bacteriology. 2009, 191:6059-6066. 21. Latifi, A., Ruiz, M. and Zhang, C.-C.*. Oxidative stress in cyanobacteria. FEMS Microbiology Reviews, 2009, 33:258-278. 22. Zhang, L.-C., Chen, Y.-F., Chen, W.-L., and Zhang, C.-C.*. Existence of periplasmic barriers preventing GFP diffusion from cell to cell in the cyanobacterium Anabaena sp. strain PCC 7120. Mol Microbiol. 2008, 70:814-823. 23. Jeanjean, R., Talla, E., Latifi, A., Havaux, M., Janicki, A., and Zhang, C.-C.*. A large gene cluster encoding peptide synthetases and polyketide synthases is involved in production of siderophores and oxidative-stress response in the cyanobacterium Anabaena sp. strain PCC 7120. Environ. Microbiol. 2008, 10:2574-2585. 24. Shi, L., Li, J.-H., Cheng, Y., Wang, L., Chen W.L. & Zhang, C.-C.*. Two genes encoding protein kinases of the HstK family are involved in the synthesis of the minor heterocyst-specific glycolipid in the cyanobacterium Anabaena sp. strain PCC 7120. Journal of bacteriology., 2007, 189:5075-5081. 2009, 191:6059-6066. 25. Jang, J., Wang, L., Jeanjean, R. & Zhang, C.-C.*. PrpJ, a PP2C-type protein phosphatase located on the plasma membrane, is involved in heterocyst maturation in the cyanobacterium Anabaena sp. PCC 7120. Mol. Microbiol. 2007, 64:247-358. 26. Latifi, A, Ruiz, M., Jeanjean, R. & Zhang, C.-C.*. PrxQ-A, a member of the peroxiredoxin Q family, plays a major role in defense against oxidative stress in the cyanobacterium Anabaena sp. PCC 7120. Free Radical Biol. Med. 2007, 42:424-431. 27. Chen, H., Laurent, S., Bédu, S., Ziarelli, F., Cheng, Y., Zhang, C.-C.* & Peng, L. Studying the signaling role of 2-oxoglutaric acid by using analogues that mimic the ketone and ketal forms of 2-oxoglutaric acid. Chemistry & Biology. 2006, 13:849-856. 28. Sakr, S., Thyssen, M., Denis, M. & Zhang, C.-C.*. Relationship among several key cell-cycle events in the developmental cyanobacterium Anabaena sp. strain PCC 7120. Journal of bacteriology. 2006, 188:5958-5965. 29. Cheng, Y., Li, J-H., Shi., L., Wang, L., Latifi, A., & Zhang, C.-C.*. A pair of iron-responsive genes encoding protein kinases with a Ser/Thr-kinase domain and a His-kinase domain are regulated by NtcA in the cyanobacterium Anabaena sp. strain PCC 7120. Journal of bacteriology. 2006, 188:4822-4829. 30. Sakr, S., Jeanjean, R., Zhang, C.-C.* & Arcondéguy, T. Inhibition of cell division suppresses heterocyst development in Anabaena sp. strain PCC 7120. Journal of bacteriology. 2006, 188:1396-1404. 31. Zhang, C.-C.*, Laurent, S., Sakr, S., Peng, L. & Bédu, S. Heterocyst differentiation and pattern formation in cyanobacteria: a chorus of signals. Mol. Microbiol. 2006, 59:367-375. 32. Latifi, A., Jeanjean, R., Lemeille, S., Havaux, M. & Zhang, C.-C.*. Iron starvation leads to oxidative stress in Anabaena sp. strain PCC 7120. Journal of bacteriology. 2005, 187:6596-6598. 33. Laurent, S., Chen, H., Bédu, S., Ziarelli, F., Peng, L*. & Zhang, C.-C.*. Nonmetabolizable analogue of 2-oxoglutarate elicits heterocyst differentiation under repressive conditions in Anabaena sp. strain PCC 7120. Proc. Natl. Acad. Sci. USA. 2005, 102:9907-9912. 34. Kuhn, I., Peng, L., Bédu, S. & Zhang, C.-C.*. Developmental regulation of the cell division protein FtsZ in Anabaena sp. strain PCC 7120, a cyanobacterium capable of terminal differentiation. Journal of bacteriology. 2000, 182:4640-4643. 35. Zhang, C-C.*, Gonzalez, L. & Phalip, V.. Survey, analysis and genetic organization of genes encoding eukaryotic-like signalling proteins by a cyanobacterial genome. Nucl. Acids Res. 1998, 26:3619-3625. 36. Zhang, C-C*., Friry, A. & Peng, L.. Molecular and genetic analysis of two closely linked genes that encode, respectively, a protein phosphatase 1/2A/2B homolog and a protein kinasehomolog in the cyanobacterium Anabaena sp. strain PCC 7120. Journal of bacteriology. 1998, 180:2616-2622. 37. Zhang, C-C.*. Bacterial signalling involving eukaryotic-type protein kinases. Mol. Microbiol. 1996, 20:9-15. 38. Zhang, C-C.*. A gene encoding a protein related to eukaryotic-type protein kinases from the filamentous heterocystous cyanobacterium Anabaena PCC 7120. Proc. Natl. Acad. Sci. USA. 1993, 90:11840-11844. 39. Zhang, C-C.*. & Bienz, M. (1992) Segmental determination in Drosophila conferred by hunchback (hb), a repressor of the homeotic gene Ultrabithorax (Ubx). Proc. Natl. Acad. Sci. USA. 89:7511-7515. 40. Zhang, C-C.*. Durand, M-C., Jeanjean, R. & Joset, F. Molecular and genetic analysis of the glucose-fructose transport system in the cyanobacterium Synechocystis PCC6803. Mol. Microbiol. 1989, 3:1221-1229. |
2001年 獲長(cháng)江學(xué)者獎勵計劃 2002年 獲國家杰出青年科學(xué)基金支助 2014年 獲法國教育科學(xué)部騎士勛章(Chevalier dans l’Ordre Académique) |
2011-2014 歐洲科學(xué)基金會(huì )(ESF)-EMBO藍細菌生物能學(xué)系列研討會(huì )副主席及主席 20221-至今 國際光營(yíng)養原核生物研討會(huì )(ISPP)國際科學(xué)委員會(huì )(ISC)成員 2008-2014 英國皇家微生物學(xué)協(xié)會(huì )期刊Microbiology執行編輯 2008-至今 美國微生物學(xué)協(xié)會(huì )期刊Journal of Bacteriology編委, 并于2015被選為top-performing reviewer members之一 2007-2020 Journal of Bacteriology編委 2021-至今 mLife副主編 |
在讀研究生: 王子乾(2017級博士)、孫慶學(xué)(2018級博士)、彭業(yè)軍(2019級博士)、劉素娟(2020級博士)、劉靜(2020級博士)、李文凱(2021級博士)、冉文碩(2021級博士)
畢業(yè)研究生: 王飛(2020年碩士畢業(yè),維亞生物科技(上海)有限公司) 黃敏(2020年博士畢業(yè),中國科學(xué)院水生生物研究所) 邢偉越(2020年博士畢業(yè),中國科學(xué)院水生生物研究所博士后) 李靜(2019年碩士畢業(yè),華中農業(yè)大學(xué)) 王心園(2019年碩士畢業(yè),中國海洋大學(xué)在讀博士)
研究生獲獎: 1. 2021年李尚諭中國科學(xué)院大學(xué)三好學(xué)生 2. 2021年冉文碩中國科學(xué)院大學(xué)三好學(xué)生 3. 2020年劉素娟中國科學(xué)院大學(xué)三好學(xué)生 4. 2019年孫慶學(xué)中國科學(xué)院大學(xué)三好學(xué)生 |