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　　副研究員，碩士生導師。2007年本科畢業(yè)于武漢大學(xué)生命科學(xué)學(xué)院;2013年于中國科學(xué)院水生生物研究所遺傳學(xué)專(zhuān)業(yè)獲博士學(xué)位。2013年進(jìn)入中國科學(xué)院水生生物研究所工作任助理研究員，2017年晉升為副研究員。2017年 入選中國科學(xué)院青年創(chuàng )新促進(jìn)會(huì )，獲得專(zhuān)項人才資助。

　　近年來(lái)，主持國家自然科學(xué)基金2項，湖北省自然科學(xué)基金1項，中國科學(xué)院特色所服務(wù)項目1項，水生所知識創(chuàng )新人才項目1項。曾榮獲中國科學(xué)院水生生物研究所青年科技獎、優(yōu)秀論文獎和中國科學(xué)院武漢分院優(yōu)秀共產(chǎn)黨員等榮譽(yù)稱(chēng)號。在學(xué)術(shù)期刊Science，EMBO Journal，Nature Communications，Nucleic Acids Research，PLoS Pathogens，Journal of Biological Chemistry，Journal of Immunology等國際經(jīng)典SCI上發(fā)表論文17篇，其中第一或共同第一作者5篇。

研究方向:

　　1)以斑馬魚(yú)作為模式生物，解析魚(yú)類(lèi)低氧耐受與低氧適應的遺傳基礎;

　　2)以斑馬魚(yú)作為模式生物，解析腫瘤發(fā)生和抗病毒天然免疫的分子機制;

　　3)解析低氧信號轉導、細胞命運決定和抗病毒天然免疫應答的調控網(wǎng)絡(luò )。

招生專(zhuān)業(yè): 遺傳學(xué)

招生方向: 魚(yú)類(lèi)低氧生物學(xué)、分子細胞生物學(xué)

　　[1] Zeshan Lin#, Lei Chen#, Xianqing Chen#, Yingbin Zhong#, Yue Yang#, Wenhao Xia#, Chang Liu, Wenbo Zhu, Han Wang, Biyao Yan, Yifeng Yang, Xing Liu, Kjersti Sternang Kvie, Knut H？kon R？ed, Kun Wang, Wuhan Xiao, Haijun Wei, Guangyu Li, Rasmus Heller, M. Thomas P. Gilbert, Qiang Qiu*, Wen Wang*, Zhipeng Li*. Biological adaptations in the Arctic cervid, the reindeer (Rangifer tarandus). Science, 2019, 364 eaav6312.

　　[2] Guangqing Yu#, Xing Liu#, Jinhua Tang, Chenxi Xu, Gang Ouyang, Wuhan Xiao*. Neddylation Facilitates the Antiviral Response in Zebrafish. Frontiers in Immunology, 2019, 10: 1432.

　　[3] Chenxi Xu, Xing Liu, Huangyuan Zha, Sijia Fan, Dawei Zhang, Wuhan Xiao*. A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1α protein. PLoS Pathogens, 2018, 18(8): e1007259.

　　[4] Xiaolian Cai, Dawei Zhang, Jing Wang, Xing Liu, Gang Ouyang, Wuhan Xiao*. Deletion of the fih gene encoding an inhibitor of hypoxia-inducible factors increases hypoxia tolerance in zebrafish. Journal of Biological Chemistry, 2018, 293(40): 15370-15380.

　　[5] Jing Wang, Dawei Zhang, Juan Du, Chi Zhou, Zhi Li, Xing Liu, Gang Ouyang, Wuhan Xiao*. Tet1 facilitates hypoxia tolerance by stabilizing the HIF-α proteins independent of its methylcytosine dioxygenase activity. Nucleic Acids Research, 2017, 45(22): 12700-12714..

　　[6] Xing Liu, Xiaolian Cai, Dawei Zhang, Chenxi Xu, Wuhan Xiao*. Zebrafish foxo3b negatively regulates anti-viral response through suppressing the transactivity of irf3 and irf7. Journal of Immunology, 2016, 197(12): 4736-4749.

　　[7] Xing Liu#, Xiaolian Cai#, Bo Hu#, Zhichao Mei, Dawei Zhang, Gang Ouyang, Jing Wang, Wei Zhang, Wuhan Xiao*. Forkhead transcription factor (FOXO3a) modulates hypoxia signaling via up-regulation of the von Hippel-Lindau gene (VHL). Journal of Biological Chemistry, 2016, 291(49): 25692-25705.

　　[8] Xing Liu, Zhu Chen, Gang Ouyang, Tieshan Song, Huageng Liang, Wei Liu, Wuhan Xiao*. ELL associated factor 2 (EAF2) inhibits transforming growth factor beta signaling through a direct interaction with Smad3. Journal of Biological Chemistry, 2015, 290(43): 25933-25945.

　　[9] Xing Liu, Zhu Chen, Chenxi Xu, Xiaoqian Leng, Hong Cao, Gang Ouyang, Wuhan Xiao*. Repression of hypoxia-inducible factor alpha signaling by Set7-mediated methylation. Nucleic Acids Research, 2015, 43(10): 5081-5098.

　　[10] Yu Chen, Chi Zhou, Wei Ji , Zhichao Mei, Bo Hu, Wei Zhang, Dawei Zhang, Jing Wang, Xing Liu, Gang Ouyang, Jiangang Zhou, Wuhan Xiao*. ELL targets c-Myc for proteasomal degradation and suppresses tumour growth. Nature Communications, 2016, 7: 11057.

　　[11] Juan Du, Dawei Zhang. Wei Zhang, Gang Ouyang, Jing Wang, Xing Liu, Sun Li, Wei Liu, Wuhan Xiao*. pVHL negatively regulates antiviral signaling by targeting MAVS for proteasomal degradation. Journal of Immunology, 2015, 195(4): 1782-1790.

　　[12] Jing Wang, Wei Zhang, Wei Ji, Xing Liu, Gang Ouyang, Wuhan Xiao*. The Von Hippel-Lindau protein suppresses androgen receptor activity. Molecular Endocrinology, 2014, 28(2): 239-248.

　　[13] Zhu Chen, Xing Liu, Zhichao Mei, Zhou Wang*, Wuhan Xiao*. EAF2 suppresses HIF-1alpha transcriptional activity by disrupting its interaction with the co-activator CBP/p300. Molecular and Cellular Biology, 2014, 34(6): 1085-1099.

　　[14] Wei Zhang, Wei Ji, Xing Liu, Gang Ouyang, Wuhan Xiao*. ELL inhibits E2F1 transcriptional activity by enhancing E2F1 deacetylation via recruitment of Histone Deacetylase 1. Molecular and Cellular Biology, 2014, 34(4): 765-775.

　　[15] Wei Ji, Jing Wang, Wei Zhang, Xing Liu, Gang Ouyang, Wuhan Xiao*. pVHL acts as a downstream target of E2F1 to suppress E2F1 activity. Biochemical Journal, 2014, 457: 185-195.

　　[16] Jing-xia Liu, Dawei Zhang, Xunwei Xie, Gang Ouyang, Xing Liu, Yonghua Sun, Wuhan Xiao*. Eaf1 and Eaf2 negatively regulate canonical Wnt/beta-catenin signaling. Development, 2013, 140: 1067-1078.

　　[17] Xi Feng, Xing Liu, Wei Zhang, Wuhan Xiao*. p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death. EMBO Journal, 2011,30: 3397-3415.