欧美日韩中文三级一区,欧美99欧美久久,日本高清www无色夜在,国产区成人综合色在线

2005.9-2009.6 武漢理工大學(xué) 生物科學(xué)與技術(shù)專(zhuān)業(yè) 本科

2009.9-2015.12 中國科學(xué)院水生生物研究所 遺傳學(xué)專(zhuān)業(yè) 博士（碩博連讀）

2016.6-2020.12 中國科學(xué)院水生生物研究所 助理研究員

2020.12-2022.12 中國科學(xué)院水生生物研究所 項目副研究員

2022.12-至今 中國科學(xué)院水生生物研究所 副研究員

1. 2023.1-2026.12 中國科學(xué)院青年創(chuàng )新促進(jìn)會(huì )會(huì )員，80萬(wàn)元，主持

2. 2023.1-2026.12 國家自然科學(xué)基金面上項目，54萬(wàn)元，主持

3. 2018.1-2020.12 國家自然科學(xué)基金青年基金，24萬(wàn)元，主持

4. 2019.9-2024.8 國家重點(diǎn)研發(fā)計劃項目子課題，48萬(wàn)元，子課題負責人

5. 2021.1-2025.12 國家自然科學(xué)基金杰出青年基金，400萬(wàn)，項目骨干

6. 2017.1-2020.12 國家自然科學(xué)基金面上項目，65萬(wàn)元，項目骨干

發(fā)現并闡明了決定魚(yú)類(lèi)卵質(zhì)的新因子—Nanog及其作用的兩個(gè)新機制：1）Nanog在早期胚胎中抑制母源β-catenin過(guò)度激活以保護胚胎發(fā)育；2）Nanog在卵子發(fā)生中通過(guò)“翻譯控制”調控母源mRNA的翻譯從而提升卵子質(zhì)量。首次發(fā)現了魚(yú)類(lèi)胚胎中微同源末端連接（MMEJ）介導的DNA雙鏈斷裂修復占主導地位，并指導實(shí)現MMEJ介導的魚(yú)類(lèi)高效基因敲入。

代表性論文：

1，He, M.D., Zhang, R., Jiao, S.B., Zhang, F.H., Ye, D., Wang, H.P., and Sun, Y.H. (2020). Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors. PLOS Biology 18, e3000561

2，He, M.D*., Jiao, S.B*., Zhang, R., Ye, D., Wang, H.P., and Sun, Y.H. (2022). Translational control by maternal Nanog promotes oogenesis and early embryonic development. Development 2022, 149(24)

3，He, M.D., Zhang, F.H., Wang, H.L., Wang, H.P., Zhu, Z.Y., and Sun, Y.H. (2015). Efficient ligase 3-dependent microhomology-mediated end joining repair of DNA double-strand breaks in zebrafish embryos. Mutation Research 780, 86-96

4，Zhang, F.H., Li, X.M., He, M.D., Ye, D., Xiong, F., Amin, G., Zhu, Z.Y., and Sun, Y.H. (2020). Efficient generation of zebrafish maternal-zygotic mutants through transplantation of ectopically induced and Cas9/gRNA targeted primordial germ cells. Journal of Genetics and Genomics 47, 37-47

5，Ye, D., Wang, X.S., Wei, C.Y., He, M.D., Wang, H.P., Wang, Y.W., Zhu, Z.Y., and Sun, Y.H. (2019). Marcksb plays a key role in the secretory pathway of zebrafish Bmp2b. PLOS Genetics 15, e1008306

6，Ye, D., Tu, Y.X., Wang, H.P., He, M.D., Wang, Y.Q., Chen, Z.F., Chen, Z.X., and Sun, Y.H. (2022). A landscape of differentiated biological processes involved in the initiation of sex differentiation in zebrafish. Water Biology and Security 1（3）10059

7，Zhang, F.H., Hao, Y.K., Li, X.M., Li, Y., Ye, D., Zhang, R., Wang, X.S., He, M.D., Wang, H.P., Zhu, Z.Y., and Sun, Y.H. (2021). Surrogate production of genome-edited sperm from a different subfamily by spermatogonial stem cell transplantation. Science China Life Science. 65, pages969–987

8，Sun, Y.H., Zhang, B., Luo, L.F., …… He, M.D. （2020） Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome Research 30, 118-126

9，Liu, C.J., Ye, D., Wang, H.P., He, M.D., and Sun, Y. H. (2020). Elovl2 But Not Elovl5 Is Essential for the Biosynthesis of Docosahexaenoic Acid (DHA) in Zebrafish: Insight from a Comparative Gene Knockout Study. Marine Biotechnology 22, 613-619.

10，Ye, D., Zhu, L., Zhang, Q.F., Xiong, F., Wang, H.P., Wang, X.S., He, M.D., Zhu, Z.Y., and Sun, Y.H. (2019). Abundance of Early Embryonic Primordial Germ Cells Promotes Zebrafish Female Differentiation as Revealed by Lifetime Labeling of Germline. Marine Biotechnology (NY) 21, 217-228

熱忱歡迎有生物學(xué)和水產(chǎn)養殖背景的學(xué)生報考。